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  • von Rohrscheidt J, Petrozziello E, Nedjic J, Federle C, Krzyzak L, Ploegh HL, Ishido S, Steinkasserer A, Klein L. Thymic CD4 T cell selection requires attenuation of March8-mediated MHCII turnover in cortical epithelial cells through CD83. J Exp Med. 2016 Aug 22;213(9):1685-94. doi: 10.1084/jem.20160316. 
  • Yamano T., Nedjic J., Hinterberger M., Steinert M., Koser S., Pinto S., Gerdes N., Lutgens E., Ishimaru N., Busslinger M., Brors B., Kyewski B., Klein L. (2015) Thymic B cells are licensed to present self antigens for central T cell tolerance induction. Immunity, 42(6): 1048-61
  • Klein L., Kyewski B., Allen P.M. and Hogquist K.A. (2014) Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see). Nature Reviews Immunology 2014 June, 14(6): 377-791.
  • Aichinger M., Wu C., Nedjic J. and Klein L. (2013) Macroautophagy substrates are loaded onto MHC Class II of medullary thymic epithelial cells for central tolerance. Journal of Experimental Medicine, 210(2): 287-300.
  • Klein L., Jovanovic K. (2011):  Regulatory T cell lineage commitment in the thymus. Seminars in Immunology, epub ahead of print; doi: 10.1016/j.smim.2011.06.003
  • Bertossi A., Aichinger M., Sansonetti P., Neff F., Pal M., Wunderlich F.T., Anders H.J., Klein L., Schmidt-Supprian M. (2011) Loss of Roquin induces early death and immune deregulation but not autoimmunity. Journal of Experimental Medicine, 208(9):1749-1756
  • Hinterberger M., Wirnsberger G., Klein L. (2011) B7 / CD28 in central tolerance costimulation promotes maturation of regulatory T cell precursosrs and prevents their clonal deletion. Frontiers in Immunology 2:30. doi: 10.3389/fimmu.2011.00030
  • Aichinger M, Hinterberger M, Klein L.: Probing gene function in medullary thymic epithelial cells. European Journal of Cell Biology, DOI: 10.1016/j.ejcb.2011.01.005
  • Wirnsberger G., Hinterberer M, Klein L.: Regulatory T-cell differentiation versus clonal deletion of autoreactive thymocytes. Immunology and Cell Biology, 2011, 89(1): 45-53
  • Klein L, Hinterberger M, von Rohrscheidt J, Aichinger M.: Autonomous versus dendritic cell dependent contributions of medullary thymic epithelial cells to central tolerance. Trends in Immunology 2011, 32(5): 188-193
  • Hinterberger M., Aichinger M., Prazeres da Costa O., Voehringer D., Hoffmann R. and Klein L. (2010).
    Autonomous role of medullary thymic epithelial cells in central CD4+ T cell  tolerance
    Nat Immunol. 2010 Jun;11(6):512-9. Epub 2010 May 2..
  • Klein L., Münz C. and Lünemann J.D. (2010).
    Autophagy-mediated antigen processing in CD4+ T cell tolerance and immunity
    FEBS Letters, 584 (7): 1405 - 1410.
  • Klein L., Hinterberger M., Wirnsberger G, Kyewski, B. (2009).
    Antigen presentation in the thymus for positive selection and central tolerance induction
    Nat Rev Immunol. 2009 Dec;9(12):833-44.
  • Klein L. 2009.
    Dead man walking  How thymocytes scan the medulla.
    Nature Immunology 10 (8):809-811.
  • Wirnsberger G., Mair F. and Klein L. (2009)
    Regulatory T cell differentiation of thymocytes does not require a dedicated antigen presenting cell but is under T cell intrinsic developmental control.
    Proceedings of the National Academy of Sciences, 106 (25):10278 - 10283. Epub June 10, 2009    Link: Presseinformation der LMU 15.06.2009
  • Nedjic J., Aichinger M., Mizushima N. and Klein L. 2009.
    Macroautophagy, endogenous MHC II loading and T cell selection: The benefits of breaking the rules.
    Current Opinion in Immunology, 2009 Feb;21(1):92-7. Epub 2009 Feb 24.
  • Nedjic J., Aichinger M., and Klein L. 2008.
    Autophagy and T cell education in the thymus: Eat yourself to know yourself.
    Cell Cycle  7 (23): 3625 - 3628
  • Nedjic J., Aichinger M., and Klein L. (2008)
    A novel role for autophagy in T cell education.
    Autophagy, 4 (8): 1090-1092
  • Nedjic J., Aichinger M., Emmerich J., Mizushima N. and Klein L. (2008)
    Autophagy in thymic epithelium shapes the T cell repertoire and is essential for tolerance.
    Nature, 455: 396-400
  • Aschenbrenner K., D’Cruz L.M., Vollmann E.H., Hinterberger M., Emmerich J., Swee L.K.,  Rolink  A. and Klein L. (2007)
    Selection of Foxp3+ regulatory T cells specific for self-antigen expressed and presented by Aire+ medullary thymic epithelial cells.
    Nature Immunology, 8 (4): 351-358.
  • Kyewski B. and Klein L. (2006)
    A central role for central T cell tolerance.
    Annual Reviews in Immunology, 24, 571-606.
  • D’Cruz L. and Klein L. (2005)
    Development and function of agonist induced CD25+Foxp3+ regulatory T cells in the absence of Interleukin 2 signaling.
    Nature Immunology, 6 (11): 1152-1159.
  • Bos R., van Duikeren S., van Hall T., Kaaijk P., Taubert R., Kyewski B., Klein L., Melief C.J. and Offringa R. (2005)
    Expression of a natural tumor antigen by thymic epithelial cells impairs the tumor protective CD4+ T cell repertoire.
    Cancer Research, 65 (14): 6443-6449.
  • Klein L., Emmerich J., d’Cruz L., Aschenbrenner K., and Khazaie K. (2005)
    Selection and Behavior of CD4+ CD25+ T Cells In Vivo: Lessons from T Cell Receptor Transgenic Models.
    Current Topics in Microbiology and Immunology, 293: 71-85.
  • Havari E., Lennon-Dumenil A.M., Klein L., Neely D., Taylor J.A., McInerney M.F., Wucherpfennig K.W., and Lipes M.A. (2004)
    Expression of the B7.1 Costimulatory Molecule on Pancreatic  Cells Abrogates the Requirement for CD4 T Cells in the Development of Type 1 Diabetes.
    The Journal of Immunology, 173: 787-796.
  • Klein L., Khazaie K., and von Boehmer H. (2003)
    In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro.
    Proceedings of the National Academy of Sciences, 100 (15): 8886-8891.
  • Jaeckel E., Klein L., Martin-Orozco N., and von Boehmer H. (2003)
    Normal incidence of diabetes in NOD mice tolerant to glutamic acid decarboxylase.
    Journal of Experimental Medicine 197 (12): 1635-1644.
  • Von Boehmer, H., Aifantis, I., Gounari, F., Azogui, O., Haughn, L., Apostolou, I., Jaeckel, E., Grassi, F., and Klein L. (2003)
    Thymic selection revisited: how essential is it?
    Immunological Reviews, 191: 62-78.
  • Klein, L., Trautman, L., Psarras, S., Schnell, S., Siermann, A., Liblau, R., von Boehmer, H., and Khazaie, K. (2003)
    Visualizing the course of antigen specific CD8 and CD4 T cell responses to a growing tumor.
    European Journal of Immunology, 33 (3):806-814.
  • Anderson, M.S., Venanzi, E.S., Klein, L., Chen, Z., Berzins, S., Turley, S.J., von Boehmer, H., Bronson, R., Dierich, A., Benoist, C., and Mathis, D. (2002)
    Projection of an immunological self-shadow within the thymus by the Aire protein.
    Science, 298: 1395-1401.
  • Jansson, M., Panoutsakopoulou, V., Baker, J., Klein, L., and Cantor, H. (2002)
    Attenuated Experimental Autoimmune Encephalomyelitis in Eta-1/Osteopontin-Deficient Mice.
    The Journal of Immunology, 168: 2096-2100.
  • Gounari F., Signoretti, S., Bronson, R., Sellers, W.R., Kum, J., Siermann, A., Klein, L., Taketo, M. M., von Boehmer, H., and Khazaie, K. (2002)
    Somatic activation of β-catenin reveals a critical event in the initiation of prostate cancer.
    Oncogene, 21(26): 4099-4107.
  • Kyewski, B., Derbinski, J., Gotter, J., and Klein, L. (2002)
    Promiscuous gene expression and central T cell tolerance: more than meets the eye.
    Trends in Immunology, 23 (7): 364-371.
  • Apostolou, I., Saroukhan, A., Klein, L., and von Boehmer, H. (2002)
    Origin of regulatory T cells with known specificity for antigen.
    Nature Immunology, 3 (8): 756-763.
  • Klein, L., Roettinger, B., and Kyewski, B. (2001)
    Sampling of complementing self-antigen pools by thymic stromal cells broadens the scope of central T-cell tolerance.
    European Journal of Immunology, 31: 2476-2486.
  • Derbinsky, J., Schulte, A., Kyewski, B. und Klein, L. (2001)
    "Promiscuous" gene expression in thymic medullary epithelial cells mirrors the "peripheral self".
    Nature Immunology, 2 (11): 1032-1039.
  • Klein L., Klugmann M, Nave KA, Tuohy V.K., Kyewski B. (2000).
    Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells.
    Nature Medicine, 6 (1): 56-61.
  • Klein L., and Kyewski, B. (2000).
    Antigen presentation by thymic stromal cells: A subtle division of labor.
    Current Opinion in Immunology, 12 (2): 179 - 186.
  • Kyewski, B., Roettinger, B., and Klein, L. (2000).
    Making T cell tolerance efficient: Thymic stromal cells sample distinct self-antigen pools.
    Current topics in Microbiology and Immunology, 251:139-145.
  • Klein L., and Kyewski, B. (2000).
    "Promiscuous" expression of tissue-antigens in the thymus: A key to T cell tolerance and autoimmunity?
    Journal of Molecular Medicine, 78 (9): 483-494.
  • Klein, L., Klein, T., Rüther, U., and Kyewski, B. (1998).
    CD4 T Cell Tolerance to Human C-reactive Protein, an Inducible Serum Protein, Is Mediated by Medullary Thymic Epithelium.
    Journal of Experimental Medicine, 188 (1): 5-16.
  • Tourne, S., Miyazaki, T., Oxenius, A., Klein, L., Fehr, T., Kyewski, B., Benoist, C. and Mathis, D. (1997).
    Selection of a broad repertoire of CD4+ T cells in H-2Ma°/° mice.
    Immunity, 7: 187-195.

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