Immunology
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Publications

Original articles

  • Fu C, Peng P, Loschko J, Feng L, Pham P, Cui W, Lee KP, Krug AB and Jiang A. (2020). Plasmacytoid dendritic cells cross-prime naive CD8 T cells by transferring antigen to conventional dendritic cells through exosomes. PNAS. https://doi.org/10.1073/pnas.2002345117

  • Huber JE, Ahlfeld J, Scheck MK, Zaucha M, Witter K, Lehmann L, Karimzadeh H, Pritsch M, Hoelscher M, von Sonnenburg F, Dick A, Barba-Spaeth G, Krug AB, Rothenfußer S, Baumjohann D. Dynamic changes in circulating T follicular helper cell composition predict neutralising antibody responses after yellow fever vaccination. Clin Transl Immunology. 2020 May 13;9(5):e1129. doi: 10.1002/cti2.1129. PMID: 32419947; PMCID: PMC7221214.
  • Metzger R, Maruskova M, Krebs S, Janssen KP, Krug AB. Increased Incidence of Colon Tumors in AOM-Treated <i>Apc</i><sup>1638N/+</sup> Mice Reveals Higher Frequency of Tumor Associated Neutrophils in Colon Than Small Intestine. Front Oncol. 2019 Oct 2;9:1001. doi: 10.3389/fonc.2019.01001. PMID: 31681563; PMCID: PMC6797844.
  • Sie C, Perez LG, Kreutzfeldt M, Potthast M, Ohnmacht C, Merkler D, Huber S, Krug A, Korn T. Dendritic Cell Accumulation in the Gut and Central Nervous System Is Differentially Dependent on α4 Integrins. J Immunol. 2019 Sep 15;203(6):1417-1427. doi: 10.4049/jimmunol.1900468. Epub 2019 Aug 9. PMID: 31399516; PMCID: PMC6731453.
  • Markota A, Metzger R, Heiseke AF, Jandl L, Dursun E, Eisenächer K, Reindl W, Haller D, Krug AB. Comparison of iron-reduced and iron-supplemented semisynthetic diets in T cell transfer colitis. PLoS One. 2019 Jul 5;14(7):e0218332. doi: 10.1371/journal.pone.0218332. PMID: 31276514; PMCID: PMC6611680.
  • Failmezger H, Dursun E, Dümcke S, Endele M, Poron D, Schroeder T, Krug A, Tresch A. Clustering of samples with a tree-shaped dependence structure, with anapplication to microscopic time lapse imaging. Bioinformatics. 2019 Jul 1;35(13):2291-2299. doi: 10.1093/bioinformatics/bty939. PMID: 30452534.

  • Musumeci A, Lutz K, Winheim E and Krug AB. What Makes a pDC: Recent Advances in Understanding Plasmacytoid DC Development and Heterogeneity. Front Immunol. 29 May 2019; 10: 1222. doi: https://doi.org/10.3389/fimmu.2019.01222. PMID: 31191558

  • Essig K, Hu D, Guimaraes JC, Alterauge D, Edelmann S, Raj T, Kranich J, Behrens G, Heiseke A, Floess S, Klein J, Maiser A, Marschall S, Hrabĕ de Angelis M, Leonhardt H, Calkhoven CF, Noessner E, Brocker T, Huehn J, Krug AB, Zavolan M, Baumjohann D, Heissmeyer V. Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells.  Immunity (2017) 47(6):1067-1082.e12. doi: 10.1016/j.immuni.2017.11.008. Epub 2017 Dec 12. PMID:29246441
  • Lehmann CHK, Baranska A, Heidkamp GF, Heger L, Neubert K, Lühr JJ, Hoffmann A, Reimer KC, Brückner C, Beck S, Seeling M, Kießling M, Soulat D, Krug AB, Ravetch JV, Leusen JHW, Nimmerjahn F, Dudziak D. DC subset-specific induction of T cell responses upon antigen uptake via Fcγ receptors in vivo.  J Exp Med. 2017 May 1;214(5):1509-1528. doi: 10.1084/jem.20160951. Epub 2017 Apr 7. PMID:28389502
  • Schuh E, Musumeci A, Thaler FS, Laurent S, Ellwart JW, Hohlfeld R, Krug AB, Meinl E. Human Plasmacytoid Dendritic Cells Display and Shed B Cell Maturation Antigen upon TLR Engagement.  J Immunol. 2017 Apr 15;198(8):3081-3088. doi: 10.4049/jimmunol.1601746. Epub 2017 Mar 10. PMID: 28283566
  • Yun TJ, Lee JS, Machmach K, Shim D, Choi J, Wi YJ, Jang HS, Jung IH, Kim K, Yoon WK, Miah MA, Li B, Chang J, Bego MG, Pham TN, Loschko J, Fritz JH, Krug AB, Lee SP, Keler T, Guimond JV, Haddad E, Cohen EA, Sirois MG, El-Hamamsy I, Colonna M, Oh GT, Choi JH, Cheong C. Indoleamine 2,3-Dioxygenase-Expressing Aortic Plasmacytoid Dendritic Cells Protect against Atherosclerosis by Induction of Regulatory T Cells.  Cell Metab. 2016 Dec 13;24(6):886. doi: 10.1016/j.cmet.2016.11.008. No abstract available. PMID:27974180
  • Dursun E., Endele M., Musumeci A., Failmezger H., Wang S.H., Tresch A., Schroeder T., Krug A.B. Continuous single cell imaging reveals sequential steps of plasmacytoid dendritic cell development from common dendritic cell progenitors. Scientific Reports (2016) 6, 37462; do:10.1038/srep37462.
  • Heiseke AF, Jeuk BH, Markota A, Straub T, Lehr HA, Reindl W, Krug AB. IRAK1 Drives Intestinal Inflammation by Promoting the Generation of Effector Th Cells with Optimal Gut-Homing Capacity. J Immunol. (2015) Dec 15;195(12):5787-94. doi: 10.4049/jimmunol.1501874.
  • Schlitzer A., McGovern N., Teo P., Zelante T., Atarashi K., Low D., Ho A. W., See P., Shin A., Wasan P. S., Hoeffel G., Malleret B., Heiseke A., Chew S., Jardine L., Purvis H. A., Hilkens C. M., Tam J., Poidinger M., Stanley E. R., Krug A. B., Renia L., Sivasankar B., Ng L. G., Collin M., Ricciardi-Castagnoli P., Honda K., Haniffa M., Ginhoux F. IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responses. Immunity (2013), 38:970-83.
  • Schlitzer A., Heiseke A. F., Einwächter H., Reindl W., Schiemann M., Manta C. P., See P., Niess J. H., Suter T, Ginhoux F, Krug A. B. Tissue-specific differentiation of a circulating CCR9- pDC-like common dendritic cell precursor. Blood (2012), 119:6063-71. 
  • Heiseke A. F., Faul A. C., Lehr H.-A., Förster I., Schmid R. M., Krug A.*, Reindl W.* * contributed equally CCL17 drives intestinal inflammation and counteracts regulatory T cell mediated protection from colitis in mice. Gastroenterology (2012), 142:335-45. 
  • Christensen J. E., Fenger C., Issazadeh-Navikas S., Krug A., Liljestrøm P., Goriely S., Paludan S. R., Finsen B., Christensen J. P., Thomsen A. R. Differential impact of interferon regulatory factor 7 in initiation of the type I interferon response in the lymphocytic choriomeningitis virus-infected central nervous system versus the periphery. Journal of Virology (2012), 86:7384-92.
  • Loschko J., Heink S., Hackl D., Dudziak D., Reindl W., Korn T., Krug A. B. Antigen targeting to plasmacytoid dendritic cells via Siglec-H inhibits Th cell-dependent autoimmunity. The Journal of Immunology (2011), 187:6346-56. 
  • Schlitzer A., Loschko L., Mair K., Vogelmann R., Henkel L., Einwächter H., Schiemann M., Niess J. H., Reindl W., Krug A. Identification of CCR9- murine plasmacytoid DC precursors with plasticity to differentiate into conventional DCs. Blood (2011), 117:6562-70. 
  • Loschko J., Schlitzer A., Dudziak D., Drexler I., Sandholzer N., Bourquin C., Reindl W., Krug A. Antigen delivery to plasmacytoid dendritic cells via BST2 induces protective T cell mediated immunity. The Journal of Immunology (2011), 186:6718-25. 
  • Hackl D., Loschko J., Sparwasser T., Reindl W., Krug A. Activation of dendritic cells via TLR7 reduces Foxp3 expression and suppressive function in induced Tregs. European Journal of Immunology (2011), 41:1334-43.
  • Rad R., Ballhorn W., Voland P., Eisenächer K., Mages J., Rad L., Ferstl R., Lang R., Wagner H., Schmid R. M., Bauer S., Prinz C., Kirschning C. J., Krug A. Extra- and Intracellular pattern recognition receptors cooperate in the recognition of Helicobacter pylori. Gastroenterology (2009) 136:2247-57. 
  • Steinberg C., Eisenächer K., Gross O., Reindl W., Schmitz F., Ruland J., Krug A. The IRF7-dependent type I IFN response is not essential for early resistance against MCMV infection. European Journal of Immunology (2009) 39:1007-18. 
  • Savarese E., Steinberg C., Pawar R. D., Reindl W., Akira S., Anders H. J., Krug A. TLR7 is required for pristane-induced snRNP antibody production and development of lupus nephritis. Arthritis and Rheumatism (2008), 58:1107-15. 
  • Cui S.*, Eisenächer K.*, Kirchhofer A., Brzózka K., Lammens A., Lammens K., Fujita T., Conzelmann K., Krug A., Hopfner K.-P. * contributed equally The C-terminal regulatory domain is the RNA 5’-triphosphate sensor of RIG-I. Molecular Cell (2008), 29:169-79. 
  • Lech M., Kulkarni O. P., Pfeiffer S., Savarese E., Krug A., Garlanda C., Mantovani A., Anders H.-J. Tir8/Sigirr prevents murine lupus by suppressing the immunostimulatory effects of lupus autoantigens. The Journal of Experimental Medicine (2008), 205:1879-88 . 
  • Gross O., Grupp C., Steinberg C., Zimmermann S., Strasser D., Hannesschlager N., Reindl W., Jonsson H., Huo H., Littman D. R., Peschel C., Yokoyama W. M., Krug A., Ruland J. Multiple ITAM-coupled NK cell receptors engage the Bcl10/Malt1 complex via Carma1 for NF-κB and MAPK activation to selectively control cytokine production. Blood (2008) 112(6):2421-8 . 
  • Fejer G., Drechsel L., Liese J., Schleicher U., Ruzsics Z., Imelli N., Greber U.F., Keck S., Hildenbrand B., Krug A., Bogdan C., Freudenberg MA. Key role of splenic myeloid DCs in the IFN-alphabeta response to adenoviruses in vivo. PLOS Pathogens (2008) 4(11):e1000208. 
  • Schmitz F., Heit A., Dreher S., Eisenächer K., Mages J., Haas T., Krug A., Janssen K.P., Kirschning C.J., Wagner H. Mammalian target of rapamycin (mTOR) orchestrates the defense program of innate immune cells. European Journal of Immunology (2008) 38:2981-92.
  • Rad R., Brenner L., Krug A., Mages J., Lang R., Voland P., Schwendy S., Reindl W., Dossumbekova A., Ballhorn W., Wagner H., Schmid R. M., Bauer S., Prinz C. Toll-like receptor-dependent activation of antigen presenting cells affects adaptive immunity to Helicobacter pylori. Gastroenterology (2007), 133:150-63.
  • Schmitz F., Heit A., Guggemoos S., Krug A., Mages J., Schiemann M., Adler H., Drexler I., Haas T., Lang R., Wagner H. Interferon-regulatory-factor 1 controls Toll-like receptor 9-mediated IFN-beta production in myeloid dendritic cells. European Journal of Immunology (2007) 37:315-27.
  • Savarese E., Chae O., Trowitzsch S., Weber G., Kastner B., Akira S., Wagner H., Schmid R. M., Bauer S., Krug A. U1 small nuclear ribonucleoprotein immune complexes induce type I interferon in plasmacytoid dendritic cells via TLR7. Blood (2006) 107:3229-34.
  • Marschner A., Rothenfusser S., Hornung V., Prell D., Krug A., Kerkmann M., Wellisch D., Poeck H., Greinacher A., Giese T., Endres S., Hartmann G. CpG ODN enhance antigen-specific NKT cell activation via plasmacytoid dendritic cells. European Journal of Immunology (2005) 35:2347-57. 
  • Barchet W., Krug A., Cella M., Newby C., Fischer J.A., Dzionek A., Pekosz A., Colonna M. Dendritic cells respond to influenza virus through TLR7- and PKR-independent pathways. European Journal of Immunology (2005) 35:236-42.
  • Krug A., French A.R., Barchet W., Fischer J.A., Dzionek A., Pingel J.T., Orihuela M.M., Akira S., Yokoyama W.M., Colonna M. TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function. Immunity (2004) 21:107-19. 
  • Krug A., Luker G. D., Barchet W., Leib D. A., Akira S., Colonna M. Herpes simplex virus type 1 (HSV-1) activates natural interferon-producing cells (IPC) through toll-like receptor 9. Blood (2004), 103:1433-7. 
  • Blasius A., Vermi W., Krug A., Facchetti F., Cella M., Colonna M. A cell surface molecule selectively expressed on murine Natural Interferon Producing Cells that blocks secretion of interferon-alpha. Blood (2004), 103:4201-6.
  • Wobus C.E., Karst S.M., Thackray L.B., Chang K.O., Sosnovtsev S.V., Belliot G., Krug A., Mackenzie J.M., Green K.Y., Virgin H.W. Replication of Norovirus in cell culture reveals a tropism for dendritic cells and macrophages. PLoS Biology (2004) 2:e432. 
  • Rothenfusser S., Hornung V., Ayyoub M., Britsch S., Towarowski A., Krug A., Sarris A., Lubenow N., Speiser D., Endres S., Hartmann G. CpG-A and CpG-B oligonucleotides differentially enhance human peptide-specific primary and memory CD8+ T-cell responses in vitro. Blood (2004) 103:2162-9.
  • Krug A., Veeraswamy R., Pekosz A., Kanagawa O., Unanue E., Colonna M., Cella M. Interferon producing cells fail to induce proliferation of naive T cells but can promote expansion and T helper 1 differentiation of antigen-experienced unpolarized T cells. The Journal of Experimental Medicine (2003), 197: 899-906. 
  • Krug A., Rothenfusser S., Selinger S., Bock C., Kerkmann M., Battiany J., Sarris A., Giese T., Speiser D., Endres S., Hartmann G. CpG-A ODN induce a monocyte-derived dendritic cell-like phenotype that preferentially activates CD8 T cells. The Journal of Immunology (2003), 170: 3468-77.
  • Krug A., Uppaluri R., Facchetti F., Dorner B., Sheehan K., Schreiber R., Cella M., Colonna M. Cutting Edge: IFN-producing cells respond to CXCR3 ligands in the presence of CXCL12 and secrete inflammatory chemokine upon activation. The Journal of Immunology (2002), 169:6079-83. 
  • Hornung V., Rothenfusser S., Britsch S., Krug A., Jahrsdörfer B., Giese T., Endres S., Hartmann G. Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. The Journal of Immunology (2002), 168:4531-7. 
  • Heckelsmiller K., Rall K., Beck S., Schlamp A., Seiderer J., Jahrsdörfer B., Krug A., Rothenfusser S., Endres S., Hartmann G. Peritumoral CpG DNA elicits a coordinated response of CD8 T cells and innate effectors to cure established tumors in a murine colon carcinoma model. The Journal of Immunology (2002), 169:3892-9. 
  • Jahrsdörfer B., Jox R., Mühlenhoff L., Tschöp K., Krug A., Rothenfusser S., Meinhardt G., Emmerich B., Endres S., Hartmann G. Modulation of malignant B cells activation and apoptosis by bcl-2 antisense ODN and immunostimulatory CpG ODN. Journal of Leucocyte Biology (2002), 72:83-92.
  • Krug A., Rothenfusser S., Hornung V., Jahrsdörfer B., Blackwell S., Ballas Z., Endres S., Krieg A., Hartmann G. Identification of CpG oligonucleotide sequences with high induction of IFN-α/-β in plasmacytoid dendritic cells. European Journal of Immunology (2001), 31:2154-63. 
  • Krug A., Towarowski A., Britsch S., Rothenfusser S., Hornung V., Bals R., Giese T., Engelmann H., Endres S., Krieg A. M., Hartmann G. Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40L to induce high amounts of IL-12. European Journal of Immunology (2001), 31:3026-37. 
  • Rothenfusser S., Hornung V., Krug A., Towarowski A., Krieg A. M., Endres S., Hartmann G. Distinct CpG oligonucleotide sequences activate human gamma delta T cells via Interferon-alpha/-beta. European Journal of Immunology (2001), 31:3525-34. 
  • Tschöp K., Hartmann G., Jox R., Thompson S., Eigler A., Krug A., Erhardt S., Adams G., Endres S., Delius M. Shock waves: a novel method for cytoplasmic delivery of antisense oligonucleotides. Journal of Molecular Medicine (2001) 79:306-13.
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