SFB 1054 Seminar - David Masopust
Title: Antiviral T Cell Memory: Migration, Function, and Applications for Cancer
Resident memory T cells (TRM) occupy tissues without recirculating and provide a first response to infections reencountered at body surfaces, where they accelerate pathogen clearance. TRM also likely play critical roles in tumor immunosurveillance, and may contribute to immune disorders, allergies, and autoimmunity. This talk will share recent and ongoing investigations of TRM function. Evidence will be presented that TRM are capable of autonomously regulating the expansion of local immunosurveillance independently of central memory or proliferation in lymphoid tissue. Data will be communicated that reveal the ontogeny of secondary lymphoid organ TRM and suggest events by which memory T cells can be regionalized to specific lymph nodes. Experiments supporting TRM developmental and migrational plasticity will be presented. A revised model of immunosurveillance will be proposed. Lastly, a novel strategy of immunotherapy for treatment of cancer will be proposed.
Host: Dietmar Zehn (B14)
If you wish to talk to the speaker, please contact Katharina.Frank@med.uni-muenchen.de