The thymus mainly contains developing thymocytes that undergo thymic selection. In addition, some mature activated peripheral T cells can re-enter the thymus. We demonstrated in this study that adoptively transferred syngeneic Ag-specific T cells can enter the thymus of lymphopenic mice.
[more] Dendritic cells (DC) are important immune effector cells. This study focused on transcriptional networks active in murine dendritic cells, but DCs are difficult to study using conventional molecular techniques. Therefore comparative promoter analysis was employed to identify evolutionarily conserved features between the murine CD11c and DC-STAMP promoters.
[more] It is currently not understood how some chronic infections exhaust antigen-specific T cells over time and which pathogen components contribute to exhaustion. Here, we dissected the behavior of primed CD4(+) T cells exposed to persistent antigen using an inducible transgenic mouse system
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