Prof. Dr. Ludger Klein
Institute for Immunology
Großhaderner Str. 9
82152 Planegg-Martinsried / Germany
Tel.: +49 (0)89 2180 75696
Tolerance to ”self” is a fundamental property of the immune system; its breakdown can lead to autoimmune diseases such as multiple sclerosis and diabetes. Selection processes in the thymus are essential for the generation of a self-tolerant T cell repertoire, either through removal of potentially dangerous T cells or through the induction of regulatory T cells. Our aim is to understand how the thymic microenvironment orchestrates these cell fate decisions.