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AG Vigo Heissmeyer

Post-transcriptional Gene Regulation in T CellsHeissmeyer_Vigo_440

Research Topics:

  • Post-transcriptional Control of T cell Differentiation
  • Function of RNA-binding Proteins and m6A RNA Methylation
  • Global Analysis of Binding Sites in the Transcriptome
  • Autoimmunity and Anti-tumor Immmunity


Prof. Dr. Vigo Heissmeyer
Biomedical Center Munich
Grosshaderner Str. 9
82152 Planegg-Martinsried / Germany
Tel.: +49 (0)89 2180 75629



T lymphocytes require well-adjusted transcriptional and post-transcriptional gene expression programs to initiate immune responses against pathogens. Surprisingly, even in the absence of infections they similarly depend on active post-transcriptional gene regulation to remain silent and not cause damage to the body’s own tissues. Our work aims to decipher how RNA-binding proteins control T cell quiescence and shape activation, differentiation and effector functions. read more

Selected Publications

Hoefig, K.P., Reim, A., Gallus, C. et al. (2021) Defining the RBPome of primary T helper cells to elucidate higher-order Roquin-mediated mRNA regulation. Nat Commun 12, 5208.,

Tavernier, S. J. et al. (2019) A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation. Nat Commun 10, 5337, doi:10.1038/s41467-019-13379-9

Essig, K. et al. (2018) Roquin targets mRNAs in a 3'-UTR-specific manner by different modes of regulation. Nat Commun 9, 3810,  doi:10.1038/s41467-018-06184-3

Jeltsch, K. M. et al. (2014) Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiation. Nat Immunol 15, 1079-1089, doi:10.1038/ni.3008

Vogel, K. U. et al. (2013) Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation. Immunity 38, 655-668, doi:10.1016/j.immuni.2012.12.004

See all publications.