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AG Thomas Brocker

Adaptive Immune Regulationthomas_brocker_440

Research Topics:

  • Immunomodulation
  • Lymphocyte interactions
  • Extracellular vesicles



Prof. Dr. Thomas Brocker
Director, Institute for Immunology
Biomedical Center Munich
Großhadernerstr. 9
82152 Planegg-Martinsried / Germany

Tel.: +49 (0)89 2180 75669
tbrocker(at)med.uni-muenchen.de

We focus our research on lymphocyte interactions in vivo. We are especially interested in Dendritic Cell (DC) biology and the immune responses resulting from DC and T lymphocytes' interactions. More precisely, we are studying the role of DCs in the induction of immunity and tolerance. Here we exploit various models of human diseases to analyze the development, function, and biology of DCs and extracellular vesicles as biomarkers and their potential immunomodulatory effects. more

Selected publications

Stutte, S., Ruf, J., Kugler, I., Ishikawa-Ankerhold, H., Parzefall, A., Marconi, P., Maeda, T., Kaisho T., Krug, A., Popper, B., Lauterbach, H., Colonna, M., von Andrian, U., Brocker, T. (2021) Type I interferon mediated induction of somatostatin leads to suppression of ghrelin and appetite thereby promoting viral immunity in mice. Brain, Behavior and Immunity (online preprint 23 Apr 2021) https://doi.org/10.1016/j.bbi.2021.04.018

Kranich, J., Chlis, N.K., Rausch, L., Latha, A., Schifferer, M., Kurz, T., Foltyn-Arfa Kia, A., Simons, M., Theis, F.J., and Brocker, T. (2020). In vivo identification of apoptotic and extracellular vesicle-bound live cells using image-based deep learning. J Extracell Vesicles 9:1792683. https://www.ncbi.nlm.nih.gov/pubmed/32944180 

Barthels, C., Ogrinc, A., Steyer, V., Meier, S., Simon, F., Wimmer, M., Blutke, A., Straub, T., Zimber-Strobl, U., Lutgens, E., Marconi, P., Ohnmacht, C., Garzetti, D., Stecher, B., and Brocker, T. (2017b). CD40-signalling abrogates induction of RORgammat(+) Treg cells by intestinal CD103(+) DCs and causes fatal colitis. Nat Commun 8:14715. https://www.ncbi.nlm.nih.gov/pubmed/28276457

Bernhard, C.A., Ried, C., Kochanek, S., and Brocker, T. (2015). CD169+ macrophages are sufficient for priming of CTLs with specificities left out by cross-priming dendritic cells. Proc Natl Acad Sci U S A 112:5461-5466. https://www.ncbi.nlm.nih.gov/pubmed/25922518

Kellersch, B., and Brocker, T. (2013). Langerhans cell homeostasis in mice is dependent on mTORC1 but not mTORC2 function. Blood 121:298-307. https://www.ncbi.nlm.nih.gov/pubmed/23212520