AG Reinhard Obst
T Cell Activation
- T cell activation
- Gene expression
- T cell receptor signaling
- Acute and chronic infections
PD Dr. Reinhard Obst
Biomedical Center Munich
82152 Planegg-Martinsried / Germany
Office: +49 (0)89 2180 75631
Lab: +49 (0)89 2180 75698
Email addresses are firstname.lastname @med.uni-muenchen.de
T cells are activated by antigen they recognize on the surface of dendritic cells in lymphoid tissues. We are interested in how the strength and length of antigen recognition affects T cell behavior. Since these parameters change over a wide range in different infections we have developed systems to change them at will to discover how T cells respond to briefly and chronically presented antigen. read more
Trefzer, A., Kadam, P., Wang, S.H., Pennavaria, S., Lober, B., Akcabozan, B., Kranich, J., Brocker, T., Nakano, N., Irmler, M., Beckers, J., Straub, T., and Obst, R. (2021). Dynamic adoption of anergy by antigen-exhausted CD4+ T cells. Cell Rep 34, 108748.
Obst, R. (2015). The timing of T cell priming and cycling. Front Immunol 6, 563.
Rabenstein, H., Behrendt, A.C., Ellwart, J.W., Naumann, R., Horsch, M., Beckers, J., and Obst, R. (2014). Differential kinetics of antigen dependency of CD4+ and CD8+ T cells. J Immunol 192, 3507-3517.
Hoerr, I., Obst, R., Rammensee, H.G., and Jung, G. (2000). In vivo application of RNA leads to induction of specific cytotoxic T lymphocytes and antibodies. Eur J Immunol 30, 1-7.