AG Ludger Klein
Immunological Tolerance
Research Topics:
- T cell Development
- Central Tolerance
- Regulatory T Cells
- Repertoire Analyses
Prof. Dr. Ludger Klein
Biomedical Center Munich
Großhaderner Str. 9
82152 Planegg-Martinsried / Germany
Tel.: +49 (0)89 2180 75696
ludger.klein(at)med.uni-muenchen.de
Tolerance to ”self” is a fundamental property of the immune system; its breakdown can lead to autoimmune diseases such as multiple sclerosis and diabetes. Selection processes in the thymus are essential for the generation of a self-tolerant T cell repertoire, either through removal of potentially dangerous T cells or through the induction of regulatory T cells. Our aim is to understand how the thymic microenvironment orchestrates these cell fate decisions. more
Selected Publications:
Hassler, T., Urmann, E., Teschner, S., Federle, C., Dileepan, T., Schober, K., Jenkins, M.K., Busch, D.H., Hinterberger, M., and Klein, L. (2019). Inventories of naive and tolerant mouse CD4 T cell repertoires reveal a hierarchy of deleted and diverted T cell receptors. Proc Natl Acad Sci U S A 116:18537-18543.
PMID: 31451631, https://www.ncbi.nlm.nih.gov/pubmed/31451631
Klein, L., Robey, E.A., and Hsieh, C.S. (2019). Central CD4(+) T cell tolerance: deletion versus regulatory T cell differentiation. Nat Rev Immunol 19:7-18.
PMID: 30420705, https://www.ncbi.nlm.nih.gov/pubmed/30420705
von Rohrscheidt, J., Petrozziello, E., Nedjic, J., Federle, C., Krzyzak, L., Ploegh, H.L., Ishido, S., Steinkasserer, A., and Klein, L. (2016). Thymic CD4 T cell selection requires attenuation of March8-mediated MHCII turnover in cortical epithelial cells through CD83. J Exp Med 213:1685-1694.
PMID: 27503071, https://www.ncbi.nlm.nih.gov/pubmed/27503071
Yamano, T., Nedjic, J., Hinterberger, M., Steinert, M., Koser, S., Pinto, S., Gerdes, N., Lutgens, E., Ishimaru, N., Busslinger, M., Brors, B., Kyewski, B., and Klein, L. (2015). Thymic B Cells Are Licensed to Present Self Antigens for Central T Cell Tolerance Induction. Immunity 42:1048-1061.
PMID: 26070482, https://www.ncbi.nlm.nih.gov/pubmed/26070482