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Original articles


Rebecca Metzger, Lis Winter, Nassim Bouznad, Debora Garzetti, Benedikt von Armansperg, Matjaz Rokavec, Konstantin Lutz, Yvonne Schäfer, Sabrina Krebs, Elena Winheim, Verena Friedrich, Dana Matzek, Rupert Öllinger, Roland Rad, Bärbel Stecher, Heiko Hermeking, Thomas Brocker, Anne B Krug (2022 Oct 17:ji2100867) CCL17 Promotes Colitis-Associated Tumorigenesis Dependent on the Microbiota. J Immunol. Online ahead of print. doi: 10.4049/jimmunol.2100867. PMID: 36253052

Ito-Kureha T, Leoni C, Borland K, Cantini G, Bataclan M, Metzger RN, Ammann G, Krug AB, Marsico A, Kaiser S, Canzar S, Feske S, Monticelli S, König J, Heissmeyer V. (2022) The function of Wtap in N6-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells. Nat Immunol. Aug 2022;23(8):1208-1221. doi: 10.1038/s41590-022-01268-1. Epub 2022 Jul 25. PMID: 35879451

Konstantin Lutz, Andrea Musumeci, Christopher Sie, Ezgi Dursun, Elena Winheim, Johannes Bagnoli, Christoph Ziegenhain, Lisa Rausch, Volker Bergen, Malte D. Luecken, Robert A. J. Oostendorp, Barbara U. Schraml, Fabian J. Theis, Wolfgang Enard, Thomas Korn & Anne B. Krug. Ly6D+Siglec-H+ precursors contribute to conventional dendritic cells via a Zbtb46+Ly6D+ intermediary stage. Nat Commun 13, 3456 (2022). PMID: 35705536; PMCID: PMC9200809


Lisa Rausch, Konstantin Lutz, Martina Schifferer, Elena Winheim, ­Rudi Gruber, Elina F. Oesterhaus, Linus Rinke, Johannes C. Hellmuth, Clemens Scherer, Maximilian Muenchhoff, Christopher Mandel, Michael Bergwelt-Baildon, Mikael Simons, Tobias Straub, Anne B. Krug, Jan Kranich, Thomas Brocker (2021) Binding of phosphatidylserine-positive microparticles by PBMCs classifies disease severity in COVID-19 patients. Journal of Extracellular Vesicles 10:14, e12173.

Winheim, E; Rinke, L; Lutz, K; Reischer, A; Leutbecher, A; Wolfram, L; Rausch, L; Kranich, J; Wratil, PR; Huber, JE; Baumjohann, D; Rothenfusser, S; Schubert, B; Hilgendorff, A; Hellmuth, JC; Scherer, C; Muenchhoff, M; von Bergwelt-Baildon, M; Stark, K; Straub, T; Brocker, T; Keppler, OT; Subklewe, M; Krug, AB (2021) Impaired function and delayed regeneration of dendritic cells in COVID-19. PLoS Pathog, 2021 vol. 17(10) e1009742
PMID: 34614036

Stutte, S., Ruf, J., Kugler, I., Ishikawa-Ankerhold, H., Parzefall, A., Marconi, P., Maeda, T., Kaisho T., Krug, A., Popper, B., Lauterbach, H., Colonna, M., von Andrian, U., Brocker, T. (2021) Type I interferon mediated induction of somatostatin leads to suppression of ghrelin and appetite thereby promoting viral immunity in mice. Brain, Behavior and Immunity.  , Vol 95, pp. 429-443.
PMID: 33895286

Friedrich, V., Forne, I., Matzek, D., Ring, D., Popper, B., Kochum, L., Spriewald, S., Straub, T., Imhof, A., Krug, A.B., Stecher, B., and Brocker, T. (2021). Helicobacter hepaticus is required for immune targeting of bacterial heat shock protein 60 and fatal colitis in mice. Gut Microbes 13:1, 1-20.
PMID: 33550886

Schraml, B.U., and Krug, A.B. (2021). Editorial for Molecular Immunology - Special issue "Novel concepts in dendritic cell development". Mol Immunol 129:112-113.
PMID: 33308901


Huber, J.E., Ahlfeld, J., Scheck, M.K., Zaucha, M., Witter, K., Lehmann, L., Karimzadeh, H., Pritsch, M., Hoelscher, M., von Sonnenburg, F., Dick, A., Barba-Spaeth, G., Krug, A.B., Rothenfußer, S., and Baumjohann, D. (2020). Dynamic changes in circulating T follicular helper cell composition predict neutralising antibody responses after yellow fever vaccination. Clin Transl Immunology 9:e1129.
PMID: 32419947

Fu, C., Peng, P., Loschko, J., Feng, L., Pham, P., Cui, W., Lee, K.P., Krug, A.B., and Jiang, A. (2020). Plasmacytoid dendritic cells cross-prime naive CD8 T cells by transferring antigen to conventional dendritic cells through exosomes. Proc Natl Acad Sci U S A 117:23730-23741.
PMID: 32879009


Sie, C., Perez, L.G., Kreutzfeldt, M., Potthast, M., Ohnmacht, C., Merkler, D., Huber, S., Krug, A., and Korn, T. (2019). Dendritic Cell Accumulation in the Gut and Central Nervous System Is Differentially Dependent on alpha4 Integrins. J Immunol 203:1417-1427.
PMID: 31399516

Musumeci, A., Lutz, K., Winheim, E., and Krug, A.B. (2019). What Makes a pDC: Recent Advances in Understanding Plasmacytoid DC Development and Heterogeneity. Frontiers in immunology 10:1222.
PMID: 31191558

Metzger, R., Maruskova, M., Krebs, S., Janssen, K.-P., and Krug, A.B. (2019). Increased Incidence of Colon Tumors in AOM-Treated Apc1638N/+ Mice Reveals Higher Frequency of Tumor Associated Neutrophils in Colon Than Small Intestine. Frontiers in Oncology 9.
PMID: 31681563

Markota, A., Metzger, R., Heiseke, A.F., Jandl, L., Dursun, E., Eisenacher, K., Reindl, W., Haller, D., and Krug, A.B. (2019). Comparison of iron-reduced and iron-supplemented semisynthetic diets in T cell transfer colitis. PloS one 14:e0218332.
PMID: 31276514

Failmezger, H., Dursun, E., Dumcke, S., Endele, M., Poron, D., Schroeder, T., Krug, A., and Tresch, A. (2019). Clustering of samples with a tree-shaped dependence structure, with an application to microscopic time lapse imaging. Bioinformatics (Oxford, England) 35:2291-2299.
PMID: 30452534


Metzger, R.N., Krug, A.B., and Eisenacher, K. (2018). Enteric Virome Sensing-Its Role in Intestinal Homeostasis and Immunity. Viruses 10.
PMID: 29570694


Schuh, E., Musumeci, A., Thaler, F.S., Laurent, S., Ellwart, J.W., Hohlfeld, R., Krug, A., and Meinl, E. (2017). Human Plasmacytoid Dendritic Cells Display and Shed B Cell Maturation Antigen upon TLR Engagement. J Immunol 198:3081-3088.
PMID: 28283566

Lehmann, C.H.K., Baranska, A., Heidkamp, G.F., Heger, L., Neubert, K., Luhr, J.J., Hoffmann, A., Reimer, K.C., Bruckner, C., Beck, S., Seeling, M., Kiessling, M., Soulat, D., Krug, A.B., Ravetch, J.V., Leusen, J.H.W., Nimmerjahn, F., and Dudziak, D. (2017). DC subset-specific induction of T cell responses upon antigen uptake via Fcgamma receptors in vivo. J Exp Med 214:1509-1528.
PMID: 28389502

Essig, K., Hu, D., Guimaraes, J.C., Alterauge, D., Edelmann, S., Raj, T., Kranich, J., Behrens, G., Heiseke, A., Floess, S., Klein, J., Maiser, A., Marschall, S., Hrabe de Angelis, M., Leonhardt, H., Calkhoven, C.F., Noessner, E., Brocker, T., Huehn, J., Krug, A.B., Zavolan, M., Baumjohann, D., and Heissmeyer, V. (2017). Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells. Immunity 47:1067-1082.e1012.
PMID: 29246441


Yun, T.J., Lee, J.S., Machmach, K., Shim, D., Choi, J., Wi, Y.J., Jang, H.S., Jung, I.H., Kim, K., Yoon, W.K., Miah, M.A., Li, B., Chang, J., Bego, M.G., Pham, T.N., Loschko, J., Fritz, J.H., Krug, A.B., Lee, S.P., Keler, T., Guimond, J.V., Haddad, E., Cohen, E.A., Sirois, M.G., El-Hamamsy, I., Colonna, M., Oh, G.T., Choi, J.H., and Cheong, C. (2016). Indoleamine 2,3-Dioxygenase-Expressing Aortic Plasmacytoid Dendritic Cells Protect against Atherosclerosis by Induction of Regulatory T Cells. Cell metabolism 24:886.
PMID: 27974180

Dursun, E., Endele, M., Musumeci, A., Failmezger, H., Wang, S.H., Tresch, A., Schroeder, T., and Krug, A.B. (2016). Continuous single cell imaging reveals sequential steps of plasmacytoid dendritic cell development from common dendritic cell progenitors. Scientific reports 6:37462.
PMID: 27892478


Schlag, C., Miehlke, S., Heiseke, A., Brockow, K., Krug, A., von Arnim, U., Straumann, A., Vieth, M., Bussmann, C., Mueller, R., Greinwald, R., and Bajbouj, M. (2015). Peripheral blood eosinophils and other non-invasive biomarkers can monitor treatment response in eosinophilic oesophagitis. Aliment Pharmacol Ther 42:1122-1130.
PMID: 26314389

Heiseke, A.F., Jeuk, B.H., Markota, A., Straub, T., Lehr, H.A., Reindl, W., and Krug, A.B. (2015). IRAK1 Drives Intestinal Inflammation by Promoting the Generation of Effector Th Cells with Optimal Gut-Homing Capacity. J Immunol 195:5787-5794.
PMID: 26561545


Heiseke, A., Eisenächer, K., and Krug, A. (2014). Nucleic acid recognition in dendritic cells. Methods Mol Biol 1169:55-65.
PMID: 24957229


Schlitzer, A., McGovern, N., Teo, P., Zelante, T., Atarashi, K., Low, D., Ho, A.W., See, P., Shin, A., Wasan, P.S., Hoeffel, G., Malleret, B., Heiseke, A., Chew, S., Jardine, L., Purvis, H.A., Hilkens, C.M., Tam, J., Poidinger, M., Stanley, E.R., Krug, A.B., Renia, L., Sivasankar, B., Ng, L.G., Collin, M., Ricciardi-Castagnoli, P., Honda, K., Haniffa, M., and Ginhoux, F. (2013). IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responses. Immunity 38:970-983.
PMID: 23706669


Schlitzer, A., Heiseke, A.F., Einwachter, H., Reindl, W., Schiemann, M., Manta, C.P., See, P., Niess, J.H., Suter, T., Ginhoux, F., and Krug, A.B. (2012). Tissue-specific differentiation of a circulating CCR9- pDC-like common dendritic cell precursor. Blood 119:6063-6071.
PMID: 22547585

Loschko, J., and Krug, A. (2012). Antigen delivery to plasmacytoid dendritic cells -induction of tolerance and immunity. Critical reviews in immunology 32:489-501.
PMID: 23428225

Heiseke, A.F., Faul, A.C., Lehr, H.A., Forster, I., Schmid, R.M., Krug, A.B.*, and Reindl, W*. (2012). CCL17 promotes intestinal inflammation in mice and counteracts regulatory T cell-mediated protection from colitis. Gastroenterology 142:335-345. *equally contributed
PMID: 22057112

Eisenächer, K., and Krug, A. (2012). Regulation of RLR-mediated innate immune signaling--it is all about keeping the balance. Eur J Cell Biol 91:36-47.
PMID: 21481967


Schlitzer, A., Loschko, J., Mair, K., Vogelmann, R., Henkel, L., Einwachter, H., Schiemann, M., Niess, J.H., Reindl, W., and Krug, A. (2011). Identification of CCR9- murine plasmacytoid DC precursors with plasticity to differentiate into conventional DCs. Blood 117:6562-6570.
PMID: 21508410

Loschko, J., Schlitzer, A., Dudziak, D., Drexler, I., Sandholzer, N., Bourquin, C., Reindl, W., and Krug, A.B. (2011a). Antigen delivery to plasmacytoid dendritic cells via BST2 induces protective T cell-mediated immunity. J Immunol 186:6718-6725.
PMID: 21555533

Loschko, J., Heink, S., Hackl, D., Dudziak, D., Reindl, W., Korn, T., and Krug, A.B. (2011b). Antigen targeting to plasmacytoid dendritic cells via Siglec-H inhibits Th cell-dependent autoimmunity. J Immunol 187:6346-6356.
PMID: 22079988

Hackl, D., Loschko, J., Sparwasser, T., Reindl, W., and Krug, A.B. (2011). Activation of dendritic cells via TLR7 reduces Foxp3 expression and suppressive function in induced Tregs. Eur J Immunol 41:1334-1343.
PMID: 21469103


Steinberg, C., Eisenächer, K., Gross, O., Reindl, W., Schmitz, F., Ruland, J., and Krug, A. (2009). The IFN regulatory factor 7-dependent type I IFN response is not essential for early resistance against murine cytomegalovirus infection. Eur J Immunol 39:1007-1018.
PMID: 19283778

Rad, R., Ballhorn, W., Voland, P., Eisenächer, K., Mages, J., Rad, L., Ferstl, R., Lang, R., Wagner, H., Schmid, R.M., Bauer, S., Prinz, C., Kirschning, C.J., and Krug, A. (2009). Extracellular and intracellular pattern recognition receptors cooperate in the recognition of Helicobacter pylori. Gastroenterology 136:2247-2257.
PMID: 19272387


Savarese, E., Steinberg, C., Pawar, R.D., Reindl, W., Akira, S., Anders, H.J., and Krug, A. (2008). Requirement of Toll-like receptor 7 for pristane-induced production of autoantibodies and development of murine lupus nephritis. Arthritis Rheum 58:1107-1115.
PMID: 18383384

Lech, M., Kulkarni, O.P., Pfeiffer, S., Savarese, E., Krug, A., Garlanda, C., Mantovani, A., and Anders, H.J. (2008). Tir8/Sigirr prevents murine lupus by suppressing the immunostimulatory effects of lupus autoantigens. J Exp Med 205:1879-1888.
PMID: 18644972

Gross, O., Grupp, C., Steinberg, C., Zimmermann, S., Strasser, D., Hannesschläger, N., Reindl, W., Jonsson, H., Huo, H., Littman, D.R., Peschel, C., Yokoyama, W.M., Krug, A., and Ruland, J. (2008). Multiple ITAM-coupled NK-cell receptors engage the Bcl10/Malt1 complex via Carma1 for NF-kappaB and MAPK activation to selectively control cytokine production. Blood 112:2421-2428.
PMID: 18192506

Cui, S., Eisenächer, K., Kirchhofer, A., Brzózka, K., Lammens, A., Lammens, K., Fujita, T., Conzelmann, K.K., Krug, A., and Hopfner, K.P. (2008). The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-I. Mol Cell 29:169-179.
PMID: 18243112

Anders, H.J., Krug, A., and Pawar, R.D. (2008). Molecular mimicry in innate immunity? The viral RNA recognition receptor TLR7 accelerates murine lupus. Eur J Immunol 38:1795-1799.
PMID: 18581336


Schmitz, F., Heit, A., Guggemoos, S., Krug, A., Mages, J., Schiemann, M., Adler, H., Drexler, I., Haas, T., Lang, R., and Wagner, H. (2007). Interferon-regulatory-factor 1 controls Toll-like receptor 9-mediated IFN-beta production in myeloid dendritic cells. Eur J Immunol 37:315-327.
PMID: 17273999,

Rad, R., Brenner, L., Krug, A., Voland, P., Mages, J., Lang, R., Schwendy, S., Reindl, W., Dossumbekova, A., Ballhorn, W., Wagner, H., Schmid, R.M., Bauer, S., and Prinz, C. (2007). Toll-like receptor-dependent activation of antigen-presenting cells affects adaptive immunity to Helicobacter pylori. Gastroenterology 133:150-163.e153.
PMID: 17631139

Eisenächer, K., Steinberg, C., Reindl, W., and Krug, A. (2007). The role of viral nucleic acid recognition in dendritic cells for innate and adaptive antiviral immunity. Immunobiology 212:701-714.
PMID: 18086372


Savarese, E., Chae, O.W., Trowitzsch, S., Weber, G., Kastner, B., Akira, S., Wagner, H., Schmid, R.M., Bauer, S., and Krug, A. (2005). U1 small nuclear ribonucleoprotein immune complexes induce type I interferon in plasmacytoid dendritic cells via TLR7. Blood.
PMID: 16368889,

Marschner, A., Rothenfusser, S., Hornung, V., Prell, D., Krug, A., Kerkmann, M., Wellisch, D., Poeck, H., Greinacher, A., Giese, T., Endres, S., and Hartmann, G. (2005). CpG ODN enhance antigen-specific NKT cell activation via plasmacytoid dendritic cells. Eur J Immunol 35:2347-2357.
PMID: 16025562,

Barchet, W., Krug, A., Cella, M., Newby, C., Fischer, J.A., Dzionek, A., Pekosz, A., and Colonna, M. (2005). Dendritic cells respond to influenza virus through TLR7- and PKR-independent pathways. Eur J Immunol 35:236-242.
PMID: 15593126,


Wobus, C.E., Karst, S.M., Thackray, L.B., Chang, K.O., Sosnovtsev, S.V., Belliot, G., Krug, A., Mackenzie, J.M., Green, K.Y., and Virgin, H.W. (2004). Replication of Norovirus in cell culture reveals a tropism for dendritic cells and macrophages. PLoS Biol 2:e432.
PMID: 15562321,

Rothenfusser, S., Hornung, V., Ayyoub, M., Britsch, S., Towarowski, A., Krug, A., Sarris, A., Lubenow, N., Speiser, D., Endres, S., and Hartmann, G. (2004). CpG-A and CpG-B oligonucleotides differentially enhance human peptide-specific primary and memory CD8+ T-cell responses in vitro. Blood 103:2162-2169.
PMID: 14630815,

Krug, A., Luker, G.D., Barchet, W., Leib, D.A., Akira, S., and Colonna, M. (2004a). Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9. Blood 103:1433-1437.
PMID: 14563635,

Krug, A., French, A.R., Barchet, W., Fischer, J.A., Dzionek, A., Pingel, J.T., Orihuela, M.M., Akira, S., Yokoyama, W.M., and Colonna, M. (2004b). TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function. Immunity 21:107-119.
PMID: 15345224,

Blasius, A., Vermi, W., Krug, A., Facchetti, F., Cella, M., and Colonna, M. (2004). A cell-surface molecule selectively expressed on murine natural interferon-producing cells that blocks secretion of interferon-alpha. Blood 103:4201-4206.
PMID: 14695235,


Krug, A., Veeraswamy, R., Pekosz, A., Kanagawa, O., Unanue, E.R., Colonna, M., and Cella, M. (2003a). Interferon-producing cells fail to induce proliferation of naive T cells but can promote expansion and T helper 1 differentiation of antigen-experienced unpolarized T cells. J Exp Med 197:899-906.
PMID: 12668648,

Krug, A., Rothenfusser, S., Selinger, S., Bock, C., Kerkmann, M., Battiany, J., Sarris, A., Giese, T., Speiser, D., Endres, S., and Hartmann, G. (2003b). CpG-A oligonucleotides induce a monocyte-derived dendritic cell-like phenotype that preferentially activates CD8 T cells. J Immunol 170:3468-3477.
PMID: 12646607,


Krug, A., Uppaluri, R., Facchetti, F., Dorner, B.G., Sheehan, K.C., Schreiber, R.D., Cella, M., and Colonna, M. (2002). IFN-producing cells respond to CXCR3 ligands in the presence of CXCL12 and secrete inflammatory chemokines upon activation. J Immunol 169:6079-6083.
PMID: 12444109,

Jahrsdorfer, B., Jox, R., Muhlenhoff, L., Tschoep, K., Krug, A., Rothenfusser, S., Meinhardt, G., Emmerich, B., Endres, S., and Hartmann, G. (2002). Modulation of malignant B cell activation and apoptosis by bcl-2 antisense ODN and immunostimulatory CpG ODN. J Leukoc Biol 72:83-92.
PMID: 12101266,

Hornung, V., Rothenfusser, S., Britsch, S., Krug, A., Jahrsdorfer, B., Giese, T., Endres, S., and Hartmann, G. (2002). Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J Immunol 168:4531-4537.
PMID: 11970999,

Heckelsmiller, K., Rall, K., Beck, S., Schlamp, A., Seiderer, J., Jahrsdorfer, B., Krug, A., Rothenfusser, S., Endres, S., and Hartmann, G. (2002). Peritumoral CpG DNA elicits a coordinated response of CD8 T cells and innate effectors to cure established tumors in a murine colon carcinoma model. J Immunol 169:3892-3899.
PMID: 12244187,

Colonna, M., Krug, A., and Cella, M. (2002). Interferon-producing cells: on the front line in immune responses against pathogens. Curr Opin Immunol 14:373-379.
PMID: 11973137,


Tschoep, K., Hartmann, G., Jox, R., Thompson, S., Eigler, A., Krug, A., Erhardt, S., Adams, G., Endres, S., and Delius, M. (2001). Shock waves: a novel method for cytoplasmic delivery of antisense oligonucleotides. J Mol Med 79:306-313.
PMID: 11485025,

Rothenfusser, S., Hornung, V., Krug, A., Towarowski, A., Krieg, A.M., Endres, S., and Hartmann, G. (2001). Distinct CpG oligonucleotide sequences activate human gamma delta T cells via interferon-alpha/-beta. Eur J Immunol 31:3525-3534.
PMID: 11745372,

Krug, A., Towarowski, A., Britsch, S., Rothenfusser, S., Hornung, V., Bals, R., Giese, T., Engelmann, H., Endres, S., Krieg, A.M., and Hartmann, G. (2001a). Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12. Eur J Immunol 31:3026-3037.
PMID: 11592079,

Krug, A., Rothenfusser, S., Hornung, V., Jahrsdorfer, B., Blackwell, S., Ballas, Z.K., Endres, S., Krieg, A.M., and Hartmann, G. (2001b). Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells. Eur J Immunol 31:2154-2163.
PMID: 11449369,

Krug, A., and Hartmann, G. (2001). [Specific modification of the immune system with CpG-oligonucleotides]. Dtsch Med Wochenschr 126:1002-1004.
PMID: 11555774,


Hartmann, G., Krug, A., Bidlingmaier, M., Hacker, U., Eigler, A., Albrecht, R., Strasburger, C.J., and Endres, S. (1998). Spontaneous and cationic lipid-mediated uptake of antisense oligonucleotides in human monocytes and lymphocytes. J Pharmacol Exp Ther 285:920-928.
PMID: 9580645,

Hartmann, G., Krug, A., Waller-Fontaine, K., and Endres, S. (1996a). Oligodeoxynucleotides enhance lipopolysaccharide-stimulated synthesis of tumor necrosis factor: dependence on phosphorothioate modification and reversal by heparin. Mol Med 2:429-438.
PMID: 8827713,

Hartmann, G., Krug, A., Eigler, A., Moeller, J., Murphy, J., Albrecht, R., and Endres, S. (1996b). Specific suppression of human tumor necrosis factor-alpha synthesis by antisense oligodeoxynucleotides. Antisense Nucleic Acid Drug Dev 6:291-299.
PMID: 9012865,