Publications
Original articles
2025
Santos-Peral A, Zaucha M, Nikolova E, Yaman E, Puzek B, Winheim E, Goresch S, Scheck MK, Lehmann L, Dahlstroem F, Karimzadeh H, Thorn-Seshold J, Jia S, Luppa F, Pritsch M, Butt J, Metz-Zumaran C, Barba-Spaeth G, Endres S, Kim-Hellmuth S, Waterboer T, Krug AB, Rothenfusser S. Basal T cell activation predicts yellow fever vaccine response independently of cytomegalovirus infection and sex-related immune variations. Cell Rep Med. 2025 Feb 18;6(2):101946. doi: 10.1016/j.xcrm.2025.101946. Epub 2025 Feb 11. PMID: 39938525.
2024
Antonio Santos-Peral, Fabian Luppa, Sebastian Goresch, Elena Nikolova, Magdalena Zaucha, Lisa Lehmann, Frank Dahlstroem, Hadi Karimzadeh, Julia Thorn-Seshold, Elena Winheim, Ev-Marie Schuster, Gerhard Dobler, Michael Hoelscher, Beate M. Kümmerer, Stefan Endres, Kilian Schober, Anne B. Krug, Michael Pritsch, Giovanna Barba-Spaeth & Simon Rothenfusser (2024 Feb 24) Prior flavivirus immunity skews the yellow fever vaccine response to cross-reactive antibodies with potential to enhance dengue virus infection. Nature Communications 15:1696. https://doi.org/10.1038/s41467-024-45806-x. PMID: 38402207
2023
Manfred B Lutz, Shafaqat Ali, Cindy Audiger, Stella E Autenrieth, Luciana Berod, Venetia Bigley, Laura Cyran, Marc Dalod, Jan Dörrie, Diana Dudziak, Georgina Flórez-Grau, Lucila Giusiano, Gloria J Godoy, Marion Heuer, Anne B Krug, Christian H K Lehmann, Christian T Mayer, Shalin H Naik, Stefanie Scheu, Gerty Schreibelt, Elodie Segura, Kristin Seré, Tim Sparwasser, Jurjen Tel, Huaming Xu, Martin Zenke (2023 Nov) Guidelines for mouse and human DC generation. Eur J Immunol 53(11):e2249816. doi: 10.1002/eji.202249816. Epub 2022 Oct 27. PMID: 36303448
2022
Elena Winheim, Tabea Eser, Flora Deák, Mohamed I. M. Ahmed, Olga Baranov, Linus Rinke, Katharina Eisenächer, Antonio Santos-Peral, Hadi Karimzadeh, Michael Pritsch, Clemens Scherer, Maximilian Muenchhoff, Johannes C. Hellmuth, Michael von Bergwelt-Baildon, Laura Olbrich, Michael Hoelscher, Andreas Wieser, Inge Kroidl, Simon Rothenfusser, Christof Geldmacher, Anne B. Krug (2022 Nov 20) Distinct and dynamic activation profiles of circulating dendritic cells and monocytes in mild COVID-19 and after yellow fever vaccination. Eur J Immunology. doi: 10.1002/eji.202250090. PMID: 36404054
Manfred B Lutz, Shafaqat Ali, Cindy Audiger, Stella E Autenrieth, Luciana Berod , Venetia Bigley, Laura Cyran , Marc Dalod, Jan Dörrie, Diana Dudziak, Georgina Flórez-Grau, Lucila Giusiano, Gloria J Godoy, Marion Heuer, Anne B Krug, Christian H K Lehmann, Christian T Mayer, Shalin H Naik, Stefanie Scheu, Gerty Schreibelt, Elodie Segura, Kristin Seré, Tim Sparwasser, Jurjen Tel, Huaming Xu, Martin Zenke (2022 Oct 27) Guidelines for mouse and human DC generation. Eur J Immunol. doi: 10.1002/eji.202249816. PMID: 36303448
Rebecca Metzger, Lis Winter, Nassim Bouznad, Debora Garzetti, Benedikt von Armansperg, Matjaz Rokavec, Konstantin Lutz, Yvonne Schäfer, Sabrina Krebs, Elena Winheim, Verena Friedrich, Dana Matzek, Rupert Öllinger, Roland Rad, Bärbel Stecher, Heiko Hermeking, Thomas Brocker, Anne B Krug (2022 Oct 17:ji2100867) CCL17 Promotes Colitis-Associated Tumorigenesis Dependent on the Microbiota. J Immunol. Online ahead of print. doi: 10.4049/jimmunol.2100867. PMID: 36253052
Ito-Kureha T, Leoni C, Borland K, Cantini G, Bataclan M, Metzger RN, Ammann G, Krug AB, Marsico A, Kaiser S, Canzar S, Feske S, Monticelli S, König J, Heissmeyer V. (2022) The function of Wtap in N6-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells. Nat Immunol. Aug 2022;23(8):1208-1221. doi: 10.1038/s41590-022-01268-1. Epub 2022 Jul 25. PMID: 35879451
Konstantin Lutz, Andrea Musumeci, Christopher Sie, Ezgi Dursun, Elena Winheim, Johannes Bagnoli, Christoph Ziegenhain, Lisa Rausch, Volker Bergen, Malte D. Luecken, Robert A. J. Oostendorp, Barbara U. Schraml, Fabian J. Theis, Wolfgang Enard, Thomas Korn & Anne B. Krug. Ly6D+Siglec-H+ precursors contribute to conventional dendritic cells via a Zbtb46+Ly6D+ intermediary stage. Nat Commun 13, 3456 (2022). https://doi.org/10.1038/s41467-022-31054-4 PMID: 35705536; PMCID: PMC9200809
2021
Lisa Rausch, Konstantin Lutz, Martina Schifferer, Elena Winheim, Rudi Gruber, Elina F. Oesterhaus, Linus Rinke, Johannes C. Hellmuth, Clemens Scherer, Maximilian Muenchhoff, Christopher Mandel, Michael Bergwelt-Baildon, Mikael Simons, Tobias Straub, Anne B. Krug, Jan Kranich, Thomas Brocker (2021) Binding of phosphatidylserine-positive microparticles by PBMCs classifies disease severity in COVID-19 patients. Journal of Extracellular Vesicles 10:14, e12173. https://doi.org/10.1002/jev2.12173
Winheim, E; Rinke, L; Lutz, K; Reischer, A; Leutbecher, A; Wolfram, L; Rausch, L; Kranich, J; Wratil, PR; Huber, JE; Baumjohann, D; Rothenfusser, S; Schubert, B; Hilgendorff, A; Hellmuth, JC; Scherer, C; Muenchhoff, M; von Bergwelt-Baildon, M; Stark, K; Straub, T; Brocker, T; Keppler, OT; Subklewe, M; Krug, AB (2021) Impaired function and delayed regeneration of dendritic cells in COVID-19. PLoS Pathog, 2021 vol. 17(10) e1009742 https://doi.org/10.1371/journal.ppat.1009742
PMID: 34614036
Stutte, S., Ruf, J., Kugler, I., Ishikawa-Ankerhold, H., Parzefall, A., Marconi, P., Maeda, T., Kaisho T., Krug, A., Popper, B., Lauterbach, H., Colonna, M., von Andrian, U., Brocker, T. (2021) Type I interferon mediated induction of somatostatin leads to suppression of ghrelin and appetite thereby promoting viral immunity in mice. Brain, Behavior and Immunity. , Vol 95, pp. 429-443. https://doi.org/10.1016/j.bbi.2021.04.018
PMID: 33895286
Friedrich, V., Forne, I., Matzek, D., Ring, D., Popper, B., Kochum, L., Spriewald, S., Straub, T., Imhof, A., Krug, A.B., Stecher, B., and Brocker, T. (2021). Helicobacter hepaticus is required for immune targeting of bacterial heat shock protein 60 and fatal colitis in mice. Gut Microbes 13:1, 1-20. https://doi.org/10.1080/19490976.2021.1882928
PMID: 33550886
Schraml, B.U., and Krug, A.B. (2021). Editorial for Molecular Immunology - Special issue "Novel concepts in dendritic cell development". Mol Immunol 129:112-113.
PMID: 33308901
2020
Huber, J.E., Ahlfeld, J., Scheck, M.K., Zaucha, M., Witter, K., Lehmann, L., Karimzadeh, H., Pritsch, M., Hoelscher, M., von Sonnenburg, F., Dick, A., Barba-Spaeth, G., Krug, A.B., Rothenfußer, S., and Baumjohann, D. (2020). Dynamic changes in circulating T follicular helper cell composition predict neutralising antibody responses after yellow fever vaccination. Clin Transl Immunology 9:e1129.
PMID: 32419947
Fu, C., Peng, P., Loschko, J., Feng, L., Pham, P., Cui, W., Lee, K.P., Krug, A.B., and Jiang, A. (2020). Plasmacytoid dendritic cells cross-prime naive CD8 T cells by transferring antigen to conventional dendritic cells through exosomes. Proc Natl Acad Sci U S A 117:23730-23741.
PMID: 32879009
2019
Sie, C., Perez, L.G., Kreutzfeldt, M., Potthast, M., Ohnmacht, C., Merkler, D., Huber, S., Krug, A., and Korn, T. (2019). Dendritic Cell Accumulation in the Gut and Central Nervous System Is Differentially Dependent on alpha4 Integrins. J Immunol 203:1417-1427.
PMID: 31399516
Musumeci, A., Lutz, K., Winheim, E., and Krug, A.B. (2019). What Makes a pDC: Recent Advances in Understanding Plasmacytoid DC Development and Heterogeneity. Frontiers in immunology 10:1222.
PMID: 31191558
Metzger, R., Maruskova, M., Krebs, S., Janssen, K.-P., and Krug, A.B. (2019). Increased Incidence of Colon Tumors in AOM-Treated Apc1638N/+ Mice Reveals Higher Frequency of Tumor Associated Neutrophils in Colon Than Small Intestine. Frontiers in Oncology 9.
https://www.frontiersin.org/article/10.3389/fonc.2019.01001
PMID: 31681563
Markota, A., Metzger, R., Heiseke, A.F., Jandl, L., Dursun, E., Eisenacher, K., Reindl, W., Haller, D., and Krug, A.B. (2019). Comparison of iron-reduced and iron-supplemented semisynthetic diets in T cell transfer colitis. PloS one 14:e0218332.
PMID: 31276514
Failmezger, H., Dursun, E., Dumcke, S., Endele, M., Poron, D., Schroeder, T., Krug, A., and Tresch, A. (2019). Clustering of samples with a tree-shaped dependence structure, with an application to microscopic time lapse imaging. Bioinformatics (Oxford, England) 35:2291-2299.
PMID: 30452534
2018
Metzger, R.N., Krug, A.B., and Eisenacher, K. (2018). Enteric Virome Sensing-Its Role in Intestinal Homeostasis and Immunity. Viruses 10.
PMID: 29570694
2017
Schuh, E., Musumeci, A., Thaler, F.S., Laurent, S., Ellwart, J.W., Hohlfeld, R., Krug, A., and Meinl, E. (2017). Human Plasmacytoid Dendritic Cells Display and Shed B Cell Maturation Antigen upon TLR Engagement. J Immunol 198:3081-3088.
PMID: 28283566
Lehmann, C.H.K., Baranska, A., Heidkamp, G.F., Heger, L., Neubert, K., Luhr, J.J., Hoffmann, A., Reimer, K.C., Bruckner, C., Beck, S., Seeling, M., Kiessling, M., Soulat, D., Krug, A.B., Ravetch, J.V., Leusen, J.H.W., Nimmerjahn, F., and Dudziak, D. (2017). DC subset-specific induction of T cell responses upon antigen uptake via Fcgamma receptors in vivo. J Exp Med 214:1509-1528.
PMID: 28389502
Essig, K., Hu, D., Guimaraes, J.C., Alterauge, D., Edelmann, S., Raj, T., Kranich, J., Behrens, G., Heiseke, A., Floess, S., Klein, J., Maiser, A., Marschall, S., Hrabe de Angelis, M., Leonhardt, H., Calkhoven, C.F., Noessner, E., Brocker, T., Huehn, J., Krug, A.B., Zavolan, M., Baumjohann, D., and Heissmeyer, V. (2017). Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells. Immunity 47:1067-1082.e1012.
PMID: 29246441
2016
Yun, T.J., Lee, J.S., Machmach, K., Shim, D., Choi, J., Wi, Y.J., Jang, H.S., Jung, I.H., Kim, K., Yoon, W.K., Miah, M.A., Li, B., Chang, J., Bego, M.G., Pham, T.N., Loschko, J., Fritz, J.H., Krug, A.B., Lee, S.P., Keler, T., Guimond, J.V., Haddad, E., Cohen, E.A., Sirois, M.G., El-Hamamsy, I., Colonna, M., Oh, G.T., Choi, J.H., and Cheong, C. (2016). Indoleamine 2,3-Dioxygenase-Expressing Aortic Plasmacytoid Dendritic Cells Protect against Atherosclerosis by Induction of Regulatory T Cells. Cell metabolism 24:886.
PMID: 27974180
Dursun, E., Endele, M., Musumeci, A., Failmezger, H., Wang, S.H., Tresch, A., Schroeder, T., and Krug, A.B. (2016). Continuous single cell imaging reveals sequential steps of plasmacytoid dendritic cell development from common dendritic cell progenitors. Scientific reports 6:37462.
PMID: 27892478
2015
Schlag, C., Miehlke, S., Heiseke, A., Brockow, K., Krug, A., von Arnim, U., Straumann, A., Vieth, M., Bussmann, C., Mueller, R., Greinwald, R., and Bajbouj, M. (2015). Peripheral blood eosinophils and other non-invasive biomarkers can monitor treatment response in eosinophilic oesophagitis. Aliment Pharmacol Ther 42:1122-1130.
PMID: 26314389
Heiseke, A.F., Jeuk, B.H., Markota, A., Straub, T., Lehr, H.A., Reindl, W., and Krug, A.B. (2015). IRAK1 Drives Intestinal Inflammation by Promoting the Generation of Effector Th Cells with Optimal Gut-Homing Capacity. J Immunol 195:5787-5794.
PMID: 26561545
2014
Heiseke, A., Eisenächer, K., and Krug, A. (2014). Nucleic acid recognition in dendritic cells. Methods Mol Biol 1169:55-65.
PMID: 24957229
2013
Schlitzer, A., McGovern, N., Teo, P., Zelante, T., Atarashi, K., Low, D., Ho, A.W., See, P., Shin, A., Wasan, P.S., Hoeffel, G., Malleret, B., Heiseke, A., Chew, S., Jardine, L., Purvis, H.A., Hilkens, C.M., Tam, J., Poidinger, M., Stanley, E.R., Krug, A.B., Renia, L., Sivasankar, B., Ng, L.G., Collin, M., Ricciardi-Castagnoli, P., Honda, K., Haniffa, M., and Ginhoux, F. (2013). IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responses. Immunity 38:970-983.
PMID: 23706669
2012
Schlitzer, A., Heiseke, A.F., Einwachter, H., Reindl, W., Schiemann, M., Manta, C.P., See, P., Niess, J.H., Suter, T., Ginhoux, F., and Krug, A.B. (2012). Tissue-specific differentiation of a circulating CCR9- pDC-like common dendritic cell precursor. Blood 119:6063-6071.
PMID: 22547585
Loschko, J., and Krug, A. (2012). Antigen delivery to plasmacytoid dendritic cells -induction of tolerance and immunity. Critical reviews in immunology 32:489-501.
PMID: 23428225
Heiseke, A.F., Faul, A.C., Lehr, H.A., Forster, I., Schmid, R.M., Krug, A.B.*, and Reindl, W*. (2012). CCL17 promotes intestinal inflammation in mice and counteracts regulatory T cell-mediated protection from colitis. Gastroenterology 142:335-345. *equally contributed
PMID: 22057112
Eisenächer, K., and Krug, A. (2012). Regulation of RLR-mediated innate immune signaling--it is all about keeping the balance. Eur J Cell Biol 91:36-47.
PMID: 21481967
2011
Schlitzer, A., Loschko, J., Mair, K., Vogelmann, R., Henkel, L., Einwachter, H., Schiemann, M., Niess, J.H., Reindl, W., and Krug, A. (2011). Identification of CCR9- murine plasmacytoid DC precursors with plasticity to differentiate into conventional DCs. Blood 117:6562-6570.
PMID: 21508410
Loschko, J., Schlitzer, A., Dudziak, D., Drexler, I., Sandholzer, N., Bourquin, C., Reindl, W., and Krug, A.B. (2011a). Antigen delivery to plasmacytoid dendritic cells via BST2 induces protective T cell-mediated immunity. J Immunol 186:6718-6725.
PMID: 21555533
Loschko, J., Heink, S., Hackl, D., Dudziak, D., Reindl, W., Korn, T., and Krug, A.B. (2011b). Antigen targeting to plasmacytoid dendritic cells via Siglec-H inhibits Th cell-dependent autoimmunity. J Immunol 187:6346-6356.
PMID: 22079988
Hackl, D., Loschko, J., Sparwasser, T., Reindl, W., and Krug, A.B. (2011). Activation of dendritic cells via TLR7 reduces Foxp3 expression and suppressive function in induced Tregs. Eur J Immunol 41:1334-1343.
PMID: 21469103
2009
Steinberg, C., Eisenächer, K., Gross, O., Reindl, W., Schmitz, F., Ruland, J., and Krug, A. (2009). The IFN regulatory factor 7-dependent type I IFN response is not essential for early resistance against murine cytomegalovirus infection. Eur J Immunol 39:1007-1018.
PMID: 19283778
Rad, R., Ballhorn, W., Voland, P., Eisenächer, K., Mages, J., Rad, L., Ferstl, R., Lang, R., Wagner, H., Schmid, R.M., Bauer, S., Prinz, C., Kirschning, C.J., and Krug, A. (2009). Extracellular and intracellular pattern recognition receptors cooperate in the recognition of Helicobacter pylori. Gastroenterology 136:2247-2257.
PMID: 19272387
2008
Savarese, E., Steinberg, C., Pawar, R.D., Reindl, W., Akira, S., Anders, H.J., and Krug, A. (2008). Requirement of Toll-like receptor 7 for pristane-induced production of autoantibodies and development of murine lupus nephritis. Arthritis Rheum 58:1107-1115.
PMID: 18383384
Lech, M., Kulkarni, O.P., Pfeiffer, S., Savarese, E., Krug, A., Garlanda, C., Mantovani, A., and Anders, H.J. (2008). Tir8/Sigirr prevents murine lupus by suppressing the immunostimulatory effects of lupus autoantigens. J Exp Med 205:1879-1888.
PMID: 18644972
Gross, O., Grupp, C., Steinberg, C., Zimmermann, S., Strasser, D., Hannesschläger, N., Reindl, W., Jonsson, H., Huo, H., Littman, D.R., Peschel, C., Yokoyama, W.M., Krug, A., and Ruland, J. (2008). Multiple ITAM-coupled NK-cell receptors engage the Bcl10/Malt1 complex via Carma1 for NF-kappaB and MAPK activation to selectively control cytokine production. Blood 112:2421-2428.
PMID: 18192506
Cui, S., Eisenächer, K., Kirchhofer, A., Brzózka, K., Lammens, A., Lammens, K., Fujita, T., Conzelmann, K.K., Krug, A., and Hopfner, K.P. (2008). The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-I. Mol Cell 29:169-179.
PMID: 18243112
Anders, H.J., Krug, A., and Pawar, R.D. (2008). Molecular mimicry in innate immunity? The viral RNA recognition receptor TLR7 accelerates murine lupus. Eur J Immunol 38:1795-1799.
PMID: 18581336
2007
Schmitz, F., Heit, A., Guggemoos, S., Krug, A., Mages, J., Schiemann, M., Adler, H., Drexler, I., Haas, T., Lang, R., and Wagner, H. (2007). Interferon-regulatory-factor 1 controls Toll-like receptor 9-mediated IFN-beta production in myeloid dendritic cells. Eur J Immunol 37:315-327.
PMID: 17273999, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17273999
Rad, R., Brenner, L., Krug, A., Voland, P., Mages, J., Lang, R., Schwendy, S., Reindl, W., Dossumbekova, A., Ballhorn, W., Wagner, H., Schmid, R.M., Bauer, S., and Prinz, C. (2007). Toll-like receptor-dependent activation of antigen-presenting cells affects adaptive immunity to Helicobacter pylori. Gastroenterology 133:150-163.e153.
PMID: 17631139
Eisenächer, K., Steinberg, C., Reindl, W., and Krug, A. (2007). The role of viral nucleic acid recognition in dendritic cells for innate and adaptive antiviral immunity. Immunobiology 212:701-714.
PMID: 18086372
2006
Savarese, E., Chae, O.W., Trowitzsch, S., Weber, G., Kastner, B., Akira, S., Wagner, H., Schmid, R.M., Bauer, S., and Krug, A. (2005). U1 small nuclear ribonucleoprotein immune complexes induce type I interferon in plasmacytoid dendritic cells via TLR7. Blood.
PMID: 16368889, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16368889
Marschner, A., Rothenfusser, S., Hornung, V., Prell, D., Krug, A., Kerkmann, M., Wellisch, D., Poeck, H., Greinacher, A., Giese, T., Endres, S., and Hartmann, G. (2005). CpG ODN enhance antigen-specific NKT cell activation via plasmacytoid dendritic cells. Eur J Immunol 35:2347-2357.
PMID: 16025562, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16025562
Barchet, W., Krug, A., Cella, M., Newby, C., Fischer, J.A., Dzionek, A., Pekosz, A., and Colonna, M. (2005). Dendritic cells respond to influenza virus through TLR7- and PKR-independent pathways. Eur J Immunol 35:236-242.
PMID: 15593126, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15593126
2004
Wobus, C.E., Karst, S.M., Thackray, L.B., Chang, K.O., Sosnovtsev, S.V., Belliot, G., Krug, A., Mackenzie, J.M., Green, K.Y., and Virgin, H.W. (2004). Replication of Norovirus in cell culture reveals a tropism for dendritic cells and macrophages. PLoS Biol 2:e432.
PMID: 15562321, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15562321
Rothenfusser, S., Hornung, V., Ayyoub, M., Britsch, S., Towarowski, A., Krug, A., Sarris, A., Lubenow, N., Speiser, D., Endres, S., and Hartmann, G. (2004). CpG-A and CpG-B oligonucleotides differentially enhance human peptide-specific primary and memory CD8+ T-cell responses in vitro. Blood 103:2162-2169.
PMID: 14630815, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=14630815
Krug, A., Luker, G.D., Barchet, W., Leib, D.A., Akira, S., and Colonna, M. (2004a). Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9. Blood 103:1433-1437.
PMID: 14563635, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=14563635
Krug, A., French, A.R., Barchet, W., Fischer, J.A., Dzionek, A., Pingel, J.T., Orihuela, M.M., Akira, S., Yokoyama, W.M., and Colonna, M. (2004b). TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function. Immunity 21:107-119.
PMID: 15345224, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15345224
Blasius, A., Vermi, W., Krug, A., Facchetti, F., Cella, M., and Colonna, M. (2004). A cell-surface molecule selectively expressed on murine natural interferon-producing cells that blocks secretion of interferon-alpha. Blood 103:4201-4206.
PMID: 14695235, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=14695235
2003
Krug, A., Veeraswamy, R., Pekosz, A., Kanagawa, O., Unanue, E.R., Colonna, M., and Cella, M. (2003a). Interferon-producing cells fail to induce proliferation of naive T cells but can promote expansion and T helper 1 differentiation of antigen-experienced unpolarized T cells. J Exp Med 197:899-906.
PMID: 12668648, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12668648
Krug, A., Rothenfusser, S., Selinger, S., Bock, C., Kerkmann, M., Battiany, J., Sarris, A., Giese, T., Speiser, D., Endres, S., and Hartmann, G. (2003b). CpG-A oligonucleotides induce a monocyte-derived dendritic cell-like phenotype that preferentially activates CD8 T cells. J Immunol 170:3468-3477.
PMID: 12646607, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12646607
2002
Krug, A., Uppaluri, R., Facchetti, F., Dorner, B.G., Sheehan, K.C., Schreiber, R.D., Cella, M., and Colonna, M. (2002). IFN-producing cells respond to CXCR3 ligands in the presence of CXCL12 and secrete inflammatory chemokines upon activation. J Immunol 169:6079-6083.
PMID: 12444109, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12444109
Jahrsdorfer, B., Jox, R., Muhlenhoff, L., Tschoep, K., Krug, A., Rothenfusser, S., Meinhardt, G., Emmerich, B., Endres, S., and Hartmann, G. (2002). Modulation of malignant B cell activation and apoptosis by bcl-2 antisense ODN and immunostimulatory CpG ODN. J Leukoc Biol 72:83-92.
PMID: 12101266, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12101266
Hornung, V., Rothenfusser, S., Britsch, S., Krug, A., Jahrsdorfer, B., Giese, T., Endres, S., and Hartmann, G. (2002). Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J Immunol 168:4531-4537.
PMID: 11970999, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11970999
Heckelsmiller, K., Rall, K., Beck, S., Schlamp, A., Seiderer, J., Jahrsdorfer, B., Krug, A., Rothenfusser, S., Endres, S., and Hartmann, G. (2002). Peritumoral CpG DNA elicits a coordinated response of CD8 T cells and innate effectors to cure established tumors in a murine colon carcinoma model. J Immunol 169:3892-3899.
PMID: 12244187, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12244187
Colonna, M., Krug, A., and Cella, M. (2002). Interferon-producing cells: on the front line in immune responses against pathogens. Curr Opin Immunol 14:373-379.
PMID: 11973137, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11973137
2001
Tschoep, K., Hartmann, G., Jox, R., Thompson, S., Eigler, A., Krug, A., Erhardt, S., Adams, G., Endres, S., and Delius, M. (2001). Shock waves: a novel method for cytoplasmic delivery of antisense oligonucleotides. J Mol Med 79:306-313.
PMID: 11485025, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11485025
Rothenfusser, S., Hornung, V., Krug, A., Towarowski, A., Krieg, A.M., Endres, S., and Hartmann, G. (2001). Distinct CpG oligonucleotide sequences activate human gamma delta T cells via interferon-alpha/-beta. Eur J Immunol 31:3525-3534.
PMID: 11745372, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11745372
Krug, A., Towarowski, A., Britsch, S., Rothenfusser, S., Hornung, V., Bals, R., Giese, T., Engelmann, H., Endres, S., Krieg, A.M., and Hartmann, G. (2001a). Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12. Eur J Immunol 31:3026-3037.
PMID: 11592079, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11592079
Krug, A., Rothenfusser, S., Hornung, V., Jahrsdorfer, B., Blackwell, S., Ballas, Z.K., Endres, S., Krieg, A.M., and Hartmann, G. (2001b). Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells. Eur J Immunol 31:2154-2163.
PMID: 11449369, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11449369
Krug, A., and Hartmann, G. (2001). [Specific modification of the immune system with CpG-oligonucleotides]. Dtsch Med Wochenschr 126:1002-1004.
PMID: 11555774, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11555774
1996-2000
Hartmann, G., Krug, A., Bidlingmaier, M., Hacker, U., Eigler, A., Albrecht, R., Strasburger, C.J., and Endres, S. (1998). Spontaneous and cationic lipid-mediated uptake of antisense oligonucleotides in human monocytes and lymphocytes. J Pharmacol Exp Ther 285:920-928.
PMID: 9580645, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9580645
Hartmann, G., Krug, A., Waller-Fontaine, K., and Endres, S. (1996a). Oligodeoxynucleotides enhance lipopolysaccharide-stimulated synthesis of tumor necrosis factor: dependence on phosphorothioate modification and reversal by heparin. Mol Med 2:429-438.
PMID: 8827713, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8827713
Hartmann, G., Krug, A., Eigler, A., Moeller, J., Murphy, J., Albrecht, R., and Endres, S. (1996b). Specific suppression of human tumor necrosis factor-alpha synthesis by antisense oligodeoxynucleotides. Antisense Nucleic Acid Drug Dev 6:291-299.
PMID: 9012865, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9012865
