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  • Trefzer, A., Kadam, P., Wang, S.H., Pennavaria, S., Lober, B., Akcabozan, B., Kranich, J., Brocker, T., Nakano, N., Irmler, M., Beckers, J., Straub, T., and Obst, R. (2021). Dynamic adoption of anergy by antigen-exhausted CD4+ T cells. Cell Rep 34, 108748. DOI:
  • Brian D. Stadinski, Reinhard Obst, Eric S. Huseby (2016) A 'hotspot' for autoimmune T cells in type 1 diabetes. JCI, Vol 126 (6), June 2016.
  • R. Obst. The timing of T cell priming and cycling. Front Immunol. 2015; 6: 563.
  • M. Voss, U. Künzel, F. Higel, P.-H. Kuhn, A. Colombo, A. Fukumori, A. Haug-Kröper, B. Klier, G. Grammer, A. Seidl, B. schröder, R. Obst, H. Steiner, S.F. Lichtenthaler, C. Haass, R. Fluhrer. Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation.
    EMBO J. (2014) 33: 2890-905.
  • H. Rabenstein, A.C. Behrendt, J.W. Ellwart, R. Naumann, M. Horsch, J. Beckers, R. Obst. Differential Kinetics of Antigen Dependency of CD4+ and CD8+ T-Cells. J. Immunol. (2014) 192: 3507-3517.
  • S Han, A. Asoyan, H. Rabenstein, N. Nakano, R. Obst
    Role of antigen persistence and dose for CD4+ T cell exhaustion and recovery.
    Proc. Natl. Acad. Sci. USA (2010) 107: 20453-20458.
  • H. Diepolder, R. Obst
    Making antigen invisible: a coinhibitory molecule regulates the interaction between T cells and dendritic cells.
    Expert Rev Vaccines (2010) 9: 243-247
  • R. Obst, H.-M. van Santen, R. Melamed, A. O. Kamphorst, C. Benoist, and D. Mathis
    Sustained antigen presentation can promote an immunogenic T cell response, like dendritic cell activation.
    Proc. Natl. Acad. Sci. USA (2007) 104: 15460-15465.
  • J. Wong, R. Obst, M. Correia-Neves, G. Losyev, D. Mathis, C. Benoist
    Adaptation of TCR repertoires to self-peptides in regulatory and nonregulatory CD4+ T cells.
    J. Immunol. (2007) 178: 7032-7041
  • G. Hyatt, R. Melamed, R. Park, R. Seguritan, C. Laplace, L. Poirot, S. Zucchelli, R. Obst, M. Matos, E. Venanzi, A. Goldrath, L. Nguyen, J. Luckey, T. Yamagata, A. Herman, J. Jacobs, D. Mathis, and C. Benoist
    Gene expression microarrays: glimpses of the immunological genome.
    Immunol. (2006) 7: 686-91
  • R. Obst*, H.-M. van Santen*, D. Mathis, and C. Benoist (*equal authorship)
    Antigen persistence is required throughout the expansion phase of a CD4+ T cell response.
    J. Exp. Med. (2005) 201: 1555-1565.
  • N. Labrecque, L. S. Whitfield, R. Obst, C. Waltzinger, C. Benoist, and D. Mathis
    How much TCR does a T cell need?
    Immunity (2001) 15: 71-82.
  • A. Jekle, R. Obst, F. Lang, H.-G. Rammensee, and E. Gulbins
    CD95/CD95 ligand-mediated counterattack does not block T cell cytotoxicity.
    Biochem. Biophys. Res. Commun. (2000) 27: 395-399
  • R. Obst, N. Netuschil, K. Klopfer, S. Stevanović, and H.-G. Rammensee
    The role of peptides in T cell alloreactivity is determined by self-major histocompatibility complex molecules.
    J. Exp. Med. (2000) 191: 805-812.
  • I. Hörr, R. Obst, H.-G. Rammensee, and G. Jung
    In vivo application of RNA leads to induction of specific cytotoxic T lymphocytes and antibodies.
    Eur. J. Immunol. (2000) 30: 1-7.
  • C. Münz, R. Obst, W. Osen, S. Stevanović, and H.-G. Rammensee
    Alloreactivity as a source of high avidity peptide-specific human CTL.
    J. Immunol. (1999) 162: 25-34
  • R. Obst, C. Münz, S. Stevanović, and H.-G. Rammensee
    Allo- and self-restricted cytotoxic T lymphocytes against a peptide library: evidence for a functionally diverse allorestricted T cell repertoire.
    Eur. J. Immunol. (1998) 28: 2432-2443
  • K. Speidel, W. Osen, S. Faath, I. Hilgert, R. Obst, J. Braspenning, F. Momburg, G. J. Hämmerling, and H.-G. Rammensee
    Priming of cytotoxic T lymphocytes by five heat-aggregated antigens in vivo: conditions, efficiency, and relation to antibody responses.
    Eur. J. Immunol. (1997) 27: 2391-2399.
  • M. Nijenhuis, S. Schmitt, E. A. Armandola, R. Obst, J. Brunner, and G. J. Hämmerling
    Identification of a contact region for peptide on the TAP1 chain of the transporter associated with antigen processing.
    J. Immunol. (1996) 156: 2186-2195.
  • R. Obst, E. A. Armandola, M. Nijenhuis, F. Momburg, and G. J. Hämmerling
    TAP polymorphism does not influence transport of peptide variants in mice and humans.
    Eur. J. Immunol. (1995) 25: 2170-2176.
  • J. Neefjes, E. Gottfried, J. Roelse, M. Grommé, R. Obst, G. J. Hämmerling, and F. Momburg
    Analysis of the fine specificity of rat, mouse and human TAP peptide transporters.
    Eur. J. Immunol. (1995) 25: 1133-1136.