Complete Publications, AG Brocker
2023
Lisa Rausch, Lavinia Flaskamp, Ashretha Ashokkumar, Anne Trefzer, Christine Ried, Veit R Buchholz, Reinhard Obst, Tobias Straub, Thomas Brocker, Jan Kranich (2023 Apr 18) Phosphatidylserine-positive extracellular vesicles boost effector CD8+ T cell responses during viral infection. PNAS 120(16):e2210047120. doi: 10.1073/pnas.2210047120
2022
Rebecca Metzger, Lis Winter, Nassim Bouznad, Debora Garzetti, Benedikt von Armansperg, Matjaz Rokavec, Konstantin Lutz, Yvonne Schäfer, Sabrina Krebs, Elena Winheim, Verena Friedrich, Dana Matzek, Rupert Öllinger, Roland Rad, Bärbel Stecher, Heiko Hermeking, Thomas Brocker, Anne B Krug (2022 Oct 17:ji2100867) CCL17 Promotes Colitis-Associated Tumorigenesis Dependent on the Microbiota. J Immunol. Online ahead of print. doi: 10.4049/jimmunol.2100867. PMID: 36253052
R. Kaiser, R. Escaig, J. Kranich, M. L. Hoffknecht, A. Anjum, V. Polewka, M. Mader, W. Hu, L. Belz, C.Gold, A. Titova, M. Lorenz, K. Pekayva, St. Kääb, F. Gaertner, K. Stark, T. Brocker, S. Massberg, L. Nicolai (April 26, 2022) Procoagulant platelet sentinels prevent inflammatory bleeding through GPIIBIIIA and GPVI. Blood. Accession Number: 35472164 DOI: 10.1182/blood.2021014914
S. Stutte, H. Ishikawa-Ankerhold, L. Lynch, S. Eickhoff, S. Nasiscionyte, C. Guo, D. van den Heuvel, D. Setzensack, M. Colonna, D. Maier-Begandt, L. Weckbach, T. Brocker, C.Schulz, B. Walzog, U van Andrian (Feb 18, 2022) High-Fat Diet Rapidly Modifies Trafficking, Phenotype, and Function of Plasmacytoid Dendritic Cells in Adipose Tissue. J Immunol (Vol. 208 Issue 6) Pages 1445-1455. Accession Number: 35181637 PMCID: PMC8919350 DOI: 10.4049/jimmunol.2100022
2021
Lisa Rausch, Konstantin Lutz, Martina Schifferer, Elena Winheim, Rudi Gruber, Elina F. Oesterhaus, Linus Rinke, Johannes C. Hellmuth, Clemens Scherer, Maximilian Muenchhoff, Christopher Mandel, Michael Bergwelt-Baildon, Mikael Simons, Tobias Straub, Anne B. Krug, Jan Kranich, Thomas Brocker (2021) Binding of phosphatidylserine-positive microparticles by PBMCs classifies disease severity in COVID-19 patients. Journal of Extracellular Vesicles. 10:14, e12173. https://doi.org/10.1002/jev2.12173.
Winheim, E; Rinke, L; Lutz, K; Reischer, A; Leutbecher, A; Wolfram, L; Rausch, L; Kranich, J; Wratil, PR; Huber, JE; Baumjohann, D; Rothenfusser, S; Schubert, B; Hilgendorff, A; Hellmuth, JC; Scherer, C; Muenchhoff, M; von Bergwelt-Baildon, M; Stark, K; Straub, T; Brocker, T; Keppler, OT; Subklewe, M; Krug, AB (2021) Impaired function and delayed regeneration of dendritic cells in COVID-19. PLoS Pathog, 2021 vol. 17(10) e1009742 https://doi.org/10.1371/journal.ppat.1009742
Stutte, S., Ruf, J., Kugler, I., Ishikawa-Ankerhold, H., Parzefall, A., Marconi, P., Maeda, T., Kaisho T., Krug, A., Popper, B., Lauterbach, H., Colonna, M., von Andrian, U., Brocker, T. (2021) Type I interferon mediated induction of somatostatin leads to suppression of ghrelin and appetite thereby promoting viral immunity in mice. Brain, Behavior and Immunity, Vol 95, pp. 429-443. https://doi.org/10.1016/j.bbi.2021.04.018
Friedrich, V., Forne, I., Matzek, D., Ring, D., Popper, B., Kochum, L., Spriewald, S., Straub, T., Imhof, A., Krug, A.B., Stecher, B., and Brocker, T. (2021). Helicobacter hepaticus is required for immune targeting of bacterial heat shock protein 60 and fatal colitis in mice. Gut Microbes 13:1, 1-20. https://doi.org/10.1080/19490976.2021.1882928
Trefzer, A., Kadam, P., Wang, S.-H., Pennavaria, S., Lober, B., Akcabozan, B., Kranich, J., Brocker, T., Nakano, N., Irmler, M., Beckers, J., Straub, T., and Obst, R. (2021). Dynamic Adoption of Anergy by Antigen-Exhausted CD4+ T Cells. Cell Reports. 34(6):108748. doi: 10.1016/j.celrep.2021.108748
2020
Chlis, N.K., Rausch, L., Brocker, T., Kranich, J., and Theis, F.J. (2020). Predicting single-cell gene expression profiles of imaging flow cytometry data with machine learning. Nucleic Acids Res 48:11335-11346.
https://www.ncbi.nlm.nih.gov/pubmed/33119742
Kranich, J., Chlis, N.K., Rausch, L., Latha, A., Schifferer, M., Kurz, T., Foltyn-Arfa Kia, A., Simons, M., Theis, F.J., and Brocker, T. (2020). In vivo identification of apoptotic and extracellular vesicle-bound live cells using image-based deep learning. J Extracell Vesicles 9:1792683.
https://www.ncbi.nlm.nih.gov/pubmed/32944180
2019
Ogrinc Wagner, A., Friedrich, V., Barthels, C., Marconi, P., Blutke, A., Brombacher, F., and Brocker, T. (2019). Strain specific maturation of Dendritic cells and production of IL-1beta controls CD40-driven colitis. PLoS One 14:e0210998.
https://www.ncbi.nlm.nih.gov/pubmed/30653608
Zwick, M., Ulas, T., Cho, Y.L., Ried, C., Grosse, L., Simon, C., Bernhard, C., Busch, D.H., Schultze, J.L., Buchholz, V.R., Stutte, S., and Brocker, T. (2019). Expression of the Phosphatase Ppef2 Controls Survival and Function of CD8(+) Dendritic Cells. Front Immunol 10:222.
https://www.ncbi.nlm.nih.gov/pubmed/30809231
Trautz, B., Wiedemann, H., Luchtenborg, C., Pierini, V., Kranich, J., Glass, B., Krausslich, H.G., Brocker, T., Pizzato, M., Ruggieri, A., Brugger, B., and Fackler, O.T. (2019). Correction: The host-cell restriction factor SERINC5 restricts HIV-1 infectivity without altering the lipid composition and organization of viral particles. J Biol Chem 294:18951.
https://www.ncbi.nlm.nih.gov/pubmed/31811051
2018
Weimershaus, M., Mauvais, F.X., Saveanu, L., Adiko, C., Babdor, J., Abramova, A., Montealegre, S., Lawand, M., Evnouchidou, I., Huber, K.J., Chadt, A., Zwick, M., Vargas, P., Dussiot, M., Lennon-Dumenil, A.M., Brocker, T., Al-Hasani, H., and van Endert, P. (2018). Innate Immune Signals Induce Anterograde Endosome Transport Promoting MHC Class I Cross-Presentation. Cell Rep 24:3568-3581.
https://www.ncbi.nlm.nih.gov/pubmed/30257216
Markey, K.A., Kuns, R.D., Browne, D.J., Gartlan, K.H., Robb, R.J., Martins, J.P., Henden, A.S., Minnie, S.A., Cheong, M., Koyama, M., Smyth, M.J., Steptoe, R.J., Belz, G.T., Brocker, T., Degli-Esposti, M.A., Lane, S.W., and Hill, G.R. (2018). Flt-3L Expansion of Recipient CD8alpha(+) Dendritic Cells Deletes Alloreactive Donor T Cells and Represents an Alternative to Posttransplant Cyclophosphamide for the Prevention of GVHD. Clin Cancer Res 24:1604-1616.
https://www.ncbi.nlm.nih.gov/pubmed/29367429
2017
Kusters, P., Seijkens, T., Burger, C., Legein, B., Winkels, H., Gijbels, M., Barthels, C., Bennett, R., Beckers, L., Atzler, D., Biessen, E., Brocker, T., Weber, C., Gerdes, N., and Lutgens, E. (2017). Constitutive CD40 Signaling in Dendritic Cells Limits Atherosclerosis by Provoking Inflammatory Bowel Disease and Ensuing Cholesterol Malabsorption. Am J Pathol 187:2912-2919.
https://www.ncbi.nlm.nih.gov/pubmed/28935569
Trautz, B., Wiedemann, H., Luchtenborg, C., Pierini, V., Kranich, J., Glass, B., Krausslich, H.G., Brocker, T., Pizzato, M., Ruggieri, A., Brugger, B., and Fackler, O.T. (2017). The host-cell restriction factor SERINC5 restricts HIV-1 infectivity without altering the lipid composition and organization of viral particles. J Biol Chem 292:13702-13713.
https://www.ncbi.nlm.nih.gov/pubmed/28659343
Barthels, C., Ogrinc, A., Steyer, V., Meier, S., Simon, F., Wimmer, M., Blutke, A., Straub, T., Zimber-Strobl, U., Lutgens, E., Marconi, P., Ohnmacht, C., Garzetti, D., Stecher, B., and Brocker, T. (2017a). Erratum: CD40-signalling abrogates induction of RORgammat(+) Treg cells by intestinal CD103(+) DCs and causes fatal colitis. Nat Commun 8:15439.
https://www.ncbi.nlm.nih.gov/pubmed/28436441
Barthels, C., Ogrinc, A., Steyer, V., Meier, S., Simon, F., Wimmer, M., Blutke, A., Straub, T., Zimber-Strobl, U., Lutgens, E., Marconi, P., Ohnmacht, C., Garzetti, D., Stecher, B., and Brocker, T. (2017b). CD40-signalling abrogates induction of RORgammat(+) Treg cells by intestinal CD103(+) DCs and causes fatal colitis. Nat Commun 8:14715.
https://www.ncbi.nlm.nih.gov/pubmed/28276457
Essig, K., Hu, D., Guimaraes, J.C., Alterauge, D., Edelmann, S., Raj, T., Kranich, J., Behrens, G., Heiseke, A., Floess, S., Klein, J., Maiser, A., Marschall, S., Hrabe de Angelis, M., Leonhardt, H., Calkhoven, C.F., Noessner, E., Brocker, T., Huehn, J., Krug, A.B., Zavolan, M., Baumjohann, D., and Heissmeyer, V. (2017). Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells. Immunity 47:1067-1082 e1012.
https://www.ncbi.nlm.nih.gov/pubmed/29246441
2016
Vargas, P., Maiuri, P., Bretou, M., Saez, P.J., Pierobon, P., Maurin, M., Chabaud, M., Lankar, D., Obino, D., Terriac, E., Raab, M., Thiam, H.R., Brocker, T., Kitchen-Goosen, S.M., Alberts, A.S., Sunareni, P., Xia, S., Li, R., Voituriez, R., Piel, M., and Lennon-Dumenil, A.M. (2016a). Innate control of actin nucleation determines two distinct migration behaviours in dendritic cells. Nat Cell Biol 18:43-53.
https://www.ncbi.nlm.nih.gov/pubmed/26641718
Meininger, I., Griesbach, R.A., Hu, D., Gehring, T., Seeholzer, T., Bertossi, A., Kranich, J., Oeckinghaus, A., Eitelhuber, A.C., Greczmiel, U., Gewies, A., Schmidt-Supprian, M., Ruland, J., Brocker, T., Heissmeyer, V., Heyd, F., and Krappmann, D. (2016). Alternative splicing of MALT1 controls signalling and activation of CD4(+) T cells. Nat Commun 7:11292.
https://www.ncbi.nlm.nih.gov/pubmed/27068814
Vargas, P., Maiuri, P., Bretou, M., Saez, P.J., Pierobon, P., Maurin, M., Chabaud, M., Lankar, D., Obino, D., Terriac, E., Raab, M., Thiam, H.R., Brocker, T., Kitchen-Goosen, S.M., Alberts, A.S., Sunareni, P., Xia, S., Li, R., Voituriez, R., Piel, M., and Lennon-Dumenil, A.M. (2016b). Corrigendum: Innate control of actin nucleation determines two distinct migration behaviours in dendritic cells. Nat Cell Biol 18:234.
https://www.ncbi.nlm.nih.gov/pubmed/26820439
2015
Schulz, A.M., Stutte, S., Hogl, S., Luckashenak, N., Dudziak, D., Leroy, C., Forne, I., Imhof, A., Muller, S.A., Brakebusch, C.H., Lichtenthaler, S.F., and Brocker, T. (2015). Cdc42-dependent actin dynamics controls maturation and secretory activity of dendritic cells. J Cell Biol 211:553-567.
https://www.ncbi.nlm.nih.gov/pubmed/26553928
Nobs, S.P., Schneider, C., Dietrich, M.G., Brocker, T., Rolink, A., Hirsch, E., and Kopf, M. (2015). PI3-Kinase-gamma Has a Distinct and Essential Role in Lung-Specific Dendritic Cell Development. Immunity 43:674-689.
https://www.ncbi.nlm.nih.gov/pubmed/26453378
Li, S., Dislich, B., Brakebusch, C.H., Lichtenthaler, S.F., and Brocker, T. (2015). Control of Homeostasis and Dendritic Cell Survival by the GTPase RhoA. J Immunol 195:4244-4256.
https://www.ncbi.nlm.nih.gov/pubmed/26408665
Bernhard, C.A., Ried, C., Kochanek, S., and Brocker, T. (2015). CD169+ macrophages are sufficient for priming of CTLs with specificities left out by cross-priming dendritic cells. Proc Natl Acad Sci U S A 112:5461-5466.
https://www.ncbi.nlm.nih.gov/pubmed/25922518
2013
Kellersch, B., and Brocker, T. (2013). Langerhans cell homeostasis in mice is dependent on mTORC1 but not mTORC2 function. Blood 121:298-307.
https://www.ncbi.nlm.nih.gov/pubmed/23212520
Luckashenak, N., Wahe, A., Breit, K., Brakebusch, C., and Brocker, T. (2013). Rho-family GTPase Cdc42 controls migration of Langerhans cells in vivo. J Immunol 190:27-35.
https://www.ncbi.nlm.nih.gov/pubmed/23209325
Kierdorf, K., Erny, D., Goldmann, T., Sander, V., Schulz, C., Perdiguero, E.G., Wieghofer, P., Heinrich, A., Riemke, P., Holscher, C., Muller, D.N., Luckow, B., Brocker, T., Debowski, K., Fritz, G., Opdenakker, G., Diefenbach, A., Biber, K., Heikenwalder, M., Geissmann, F., Rosenbauer, F., and Prinz, M. (2013). Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways. Nat Neurosci 16:273-280.
https://www.ncbi.nlm.nih.gov/pubmed/23334579
Huang, J., Li, X., Kohno, K., Hatano, M., Tokuhisa, T., Murray, P.J., Brocker, T., and Tsuji, M. (2013). Generation of tissue-specific H-2Kd transgenic mice for the study of K(d)-restricted malaria epitope-specific CD8+ T-cell responses in vivo. J Immunol Methods 387:254-261.
https://www.ncbi.nlm.nih.gov/pubmed/23142461
Barthels, C., Puchalka, J., Racek, T., Klein, C., and Brocker, T. (2013). Novel spontaneous deletion of artemis exons 10 and 11 in mice leads to T- and B-cell deficiency. PLoS One 8:e74838.
https://www.ncbi.nlm.nih.gov/pubmed/24069355
2012
Nopora, K., Bernhard, C.A., Ried, C., Castello, A.A., Murphy, K.M., Marconi, P., Koszinowski, U., and Brocker, T. (2012). MHC class I cross-presentation by dendritic cells counteracts viral immune evasion. Front Immunol 3:348.
https://www.ncbi.nlm.nih.gov/pubmed/23189079
Richter, K., Brocker, T., and Oxenius, A. (2012). Antigen amount dictates CD8+ T-cell exhaustion during chronic viral infection irrespective of the type of antigen presenting cell. Eur J Immunol 42:2290-2304.
https://www.ncbi.nlm.nih.gov/pubmed/22653665
Friedrich, R.I., Nopora, K., and Brocker, T. (2012). Transcriptional targeting of B cells with viral vectors. Eur J Cell Biol 91:86-96.
https://www.ncbi.nlm.nih.gov/pubmed/21458103
2011
Edelmann, S.L., Nelson, P.J., and Brocker, T. (2011a). Comparative promoter analysis in vivo: identification of a dendritic cell-specific promoter module. Blood 118:e40-49.
https://www.ncbi.nlm.nih.gov/pubmed/21659543
Edelmann, S.L., Marconi, P., and Brocker, T. (2011b). Peripheral T cells re-enter the thymus and interfere with central tolerance induction. J Immunol 186:5612-5619.
https://www.ncbi.nlm.nih.gov/pubmed/21471449
Turner, M.L., Schnorfeil, F.M., and Brocker, T. (2011). MicroRNAs regulate dendritic cell differentiation and function. J Immunol 187:3911-3917.
https://www.ncbi.nlm.nih.gov/pubmed/21969315
Torti, N., Walton, S.M., Brocker, T., Rulicke, T., and Oxenius, A. (2011). Non-hematopoietic cells in lymph nodes drive memory CD8 T cell inflation during murine cytomegalovirus infection. PLoS Pathog 7:e1002313.
https://www.ncbi.nlm.nih.gov/pubmed/22046127
Argnani, R., Marconi, P., Volpi, I., Bolanos, E., Carro, E., Ried, C., Santamaria, E., Pourchet, A., Epstein, A.L., Brocker, T., Corrales, F.J., Manservigi, R., Goicoechea, I., Foschini, M., and Hernandez-Alcoceba, R. (2011). Characterization of herpes simplex virus 1 strains as platforms for the development of oncolytic viruses against liver cancer. Liver Int 31:1542-1553.
https://www.ncbi.nlm.nih.gov/pubmed/22093330
2010
Gruber, A., Cannarile, M.A., Cheminay, C., Ried, C., Marconi, P., Hacker, G., and Brocker, T. (2010). Parenchymal cells critically curtail cytotoxic T-cell responses by inducing Bim-mediated apoptosis. Eur J Immunol 40:966-975.
https://www.ncbi.nlm.nih.gov/pubmed/20127674
Kuipers, H., Schnorfeil, F.M., Fehling, H.J., Bartels, H., and Brocker, T. (2010a). Dicer-dependent microRNAs control maturation, function, and maintenance of Langerhans cells in vivo. J Immunol 185:400-409.
https://www.ncbi.nlm.nih.gov/pubmed/20530258
Kuipers, H., Schnorfeil, F.M., and Brocker, T. (2010b). Differentially expressed microRNAs regulate plasmacytoid vs. conventional dendritic cell development. Mol Immunol 48:333-340.
https://www.ncbi.nlm.nih.gov/pubmed/20822813
2009
Ohnmacht, C., Pullner, A., King, S.B., Drexler, I., Meier, S., Brocker, T., and Voehringer, D. (2009). Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity. J Exp Med 206:549-559.
https://www.ncbi.nlm.nih.gov/pubmed/19237601
2008
Luckashenak, N., Schroeder, S., Endt, K., Schmidt, D., Mahnke, K., Bachmann, M.F., Marconi, P., Deeg, C.A., and Brocker, T. (2008). Constitutive crosspresentation of tissue antigens by dendritic cells controls CD8+ T cell tolerance in vivo. Immunity 28:521-532.
https://www.ncbi.nlm.nih.gov/pubmed/18387832
Dresch, C., Edelmann, S.L., Marconi, P., and Brocker, T. (2008). Lentiviral-mediated transcriptional targeting of dendritic cells for induction of T cell tolerance in vivo. J Immunol 181:4495-4506.
https://www.ncbi.nlm.nih.gov/pubmed/18802052
2007
Werner-Klein, M., Dresch, C., Marconi, P., and Brocker, T. (2007). Transcriptional targeting of B cells for induction of peripheral CD8 T cell tolerance. J Immunol 178:7738-7746.
https://www.ncbi.nlm.nih.gov/pubmed/17548611
Sethi, S., Kerksiek, K.M., Brocker, T., and Kretzschmar, H. (2007). Role of the CD8+ dendritic cell subset in transmission of prions. J Virol 81:4877-4880.
https://www.ncbi.nlm.nih.gov/pubmed/17301133
2006
Neuenhahn, M., Kerksiek, K.M., Nauerth, M., Suhre, M.H., Schiemann, M., Gebhardt, F.E., Stemberger, C., Panthel, K., Schroder, S., Chakraborty, T., Jung, S., Hochrein, H., Russmann, H., Brocker, T., and Busch, D.H. (2006). CD8alpha+ dendritic cells are required for efficient entry of Listeria monocytogenes into the spleen. Immunity 25:619-630.
https://www.ncbi.nlm.nih.gov/pubmed/17027298
Lauterbach, H., Gruber, A., Ried, C., Cheminay, C., and Brocker, T. (2006). Insufficient APC capacities of dendritic cells in gene gun-mediated DNA vaccination. J Immunol 176:4600-4607.
https://www.ncbi.nlm.nih.gov/pubmed/16585550
2005
Gruber, A., and Brocker, T. (2005). MHC class I-positive dendritic cells (DC) control CD8 T cell homeostasis in vivo: T cell lymphopenia as a prerequisite for DC-mediated homeostatic proliferation of naive CD8 T cells. J Immunol 175:201-206.
https://www.ncbi.nlm.nih.gov/pubmed/15972649
Hon, H., Oran, A., Brocker, T., and Jacob, J. (2005). B lymphocytes participate in cross-presentation of antigen following gene gun vaccination. J Immunol 174:5233-5242.
https://www.ncbi.nlm.nih.gov/pubmed/15843519
Kleindienst, P., Wiethe, C., Lutz, M.B., and Brocker, T. (2005). Simultaneous induction of CD4 T cell tolerance and CD8 T cell immunity by semimature dendritic cells. J Immunol 174:3941-3947.
https://www.ncbi.nlm.nih.gov/pubmed/15778350
Kleindienst, P., and Brocker, T. (2005). Concerted antigen presentation by dendritic cells and B cells is necessary for optimal CD4 T-cell immunity in vivo. Immunology 115:556-564.
https://www.ncbi.nlm.nih.gov/pubmed/16011524
Kerksiek, K.M., Niedergang, F., Chavrier, P., Busch, D.H., and Brocker, T. (2005). Selective Rac1 inhibition in dendritic cells diminishes apoptotic cell uptake and cross-presentation in vivo. Blood 105:742-749.
https://www.ncbi.nlm.nih.gov/pubmed/15383465
Lauterbach, H., Ried, C., Epstein, A.L., Marconi, P., and Brocker, T. (2005). Reduced immune responses after vaccination with a recombinant herpes simplex virus type 1 vector in the presence of antiviral immunity. J Gen Virol 86:2401-2410.
https://www.ncbi.nlm.nih.gov/pubmed/16099897
2004
Werner, M., Kraunus, J., Baum, C., and Brocker, T. (2004). B-cell-specific transgene expression using a self-inactivating retroviral vector with human CD19 promoter and viral post-transcriptional regulatory element. Gene Ther 11:992-1000.
https://www.ncbi.nlm.nih.gov/pubmed/15029232
Cannarile, M.A., Decanis, N., van Meerwijk, J.P., and Brocker, T. (2004). The role of dendritic cells in selection of classical and nonclassical CD8+ T cells in vivo. J Immunol 173:4799-4805.
https://www.ncbi.nlm.nih.gov/pubmed/15470019
Lauterbach, H., Kerksiek, K.M., Busch, D.H., Berto, E., Bozac, A., Mavromara, P., Manservigi, R., Epstein, A.L., Marconi, P., and Brocker, T. (2004). Protection from bacterial infection by a single vaccination with replication-deficient mutant herpes simplex virus type 1. J Virol 78:4020-4028.
https://www.ncbi.nlm.nih.gov/pubmed/15047818
2003
Kleindienst, P., and Brocker, T. (2003). Endogenous dendritic cells are required for amplification of T cell responses induced by dendritic cell vaccines in vivo. J Immunol 170:2817-2823.
https://www.ncbi.nlm.nih.gov/pubmed/12626531
Schipf, A., Heilmann, A., Boue, L., Mossmann, H., Brocker, T., and Rocken, M. (2003). Th2 cells shape the differentiation of developing T cell responses during interactions with dendritic cells in vivo. Eur J Immunol 33:1697-1706.
https://www.ncbi.nlm.nih.gov/pubmed/12778488
Annenkov, A.E., Daly, G.M., Brocker, T., and Chernajovsky, Y. (2003). Clustering of immunoreceptor tyrosine-based activation motif-containing signalling subunits in CD4(+) T cells is an optimal signal for IFN-gamma production, but not for the production of IL-4. Int Immunol 15:665-677.
https://www.ncbi.nlm.nih.gov/pubmed/12697666
2002
Nopora, A., and Brocker, T. (2002). Bcl-2 controls dendritic cell longevity in vivo. J Immunol 169:3006-3014.
https://www.ncbi.nlm.nih.gov/pubmed/12218115
2001
Kurts, C., Cannarile, M., Klebba, I., and Brocker, T. (2001). Dendritic cells are sufficient to cross-present self-antigens to CD8 T cells in vivo. J Immunol 166:1439-1442.
https://www.ncbi.nlm.nih.gov/pubmed/11160180
Kirberg, J., von Boehmer, H., Brocker, T., Rodewald, H.R., and Takeda, S. (2001). Class II essential for CD4 survival. Nat Immunol 2:136-137.
https://www.ncbi.nlm.nih.gov/pubmed/11175806
2000
Kleindienst, P., Chretien, I., Winkler, T., and Brocker, T. (2000). Functional comparison of thymic B cells and dendritic cells in vivo. Blood 95:2610-2616.
https://www.ncbi.nlm.nih.gov/pubmed/10753841
Brocker, T. (2000). Chimeric Fv-zeta or Fv-epsilon receptors are not sufficient to induce activation or cytokine production in peripheral T cells. Blood 96:1999-2001.
Walker, L.S., Gulbranson-Judge, A., Flynn, S., Brocker, T., and Lane, P.J. (2000). Co-stimulation and selection for T-cell help for germinal centres: the role of CD28 and OX40. Immunol Today 21:333-337.
https://www.ncbi.nlm.nih.gov/pubmed/10871874
van Essen, D., Dullforce, P., Brocker, T., and Gray, D. (2000). Cellular interactions involved in Th cell memory. J Immunol 165:3640-3646.
https://www.ncbi.nlm.nih.gov/pubmed/11034367
1988-1999
Baribaud, F., Maillard, I., Vacheron, S., Brocker, T., Diggelmann, H., and Acha-Orbea, H. (1999). Role of dendritic cells in the immune response induced by mouse mammary tumor virus superantigen. J Virol 73:8403-8410.
https://www.ncbi.nlm.nih.gov/pubmed/10482591
Walker, L.S., Gulbranson-Judge, A., Flynn, S., Brocker, T., Raykundalia, C., Goodall, M., Forster, R., Lipp, M., and Lane, P. (1999). Compromised OX40 function in CD28-deficient mice is linked with failure to develop CXC chemokine receptor 5-positive CD4 cells and germinal centers. J Exp Med 190:1115-1122.
https://www.ncbi.nlm.nih.gov/pubmed/10523609
Lane, P.J., and Brocker, T. (1999). Developmental regulation of dendritic cell function. Curr Opin Immunol 11:308-313.
https://www.ncbi.nlm.nih.gov/pubmed/10375555
Rolink, A.G., Brocker, T., Bluethmann, H., Kosco-Vilbois, M.H., Andersson, J., and Melchers, F. (1999). Mutations affecting either generation or survival of cells influence the pool size of mature B cells. Immunity 10:619-628.
https://www.ncbi.nlm.nih.gov/pubmed/10367907
Brocker, T., Gulbranson-Judge, A., Flynn, S., Riedinger, M., Raykundalia, C., and Lane, P. (1999). CD4 T cell traffic control: in vivo evidence that ligation of OX40 on CD4 T cells by OX40-ligand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles. Eur J Immunol 29:1610-1616.
https://www.ncbi.nlm.nih.gov/pubmed/10359115
Rodewald, H.R., Brocker, T., and Haller, C. (1999). Developmental dissociation of thymic dendritic cell and thymocyte lineages revealed in growth factor receptor mutant mice. Proc Natl Acad Sci U S A 96:15068-15073.
https://www.ncbi.nlm.nih.gov/pubmed/10611339
Brocker, T. (1999). The role of dendritic cells in T cell selection and survival. J Leukoc Biol 66:331-335.
https://www.ncbi.nlm.nih.gov/pubmed/10449177
Brocker, T., and Karjalainen, K. (1998). Adoptive tumor immunity mediated by lymphocytes bearing modified antigen-specific receptors. Adv Immunol 68:257-269.
https://www.ncbi.nlm.nih.gov/pubmed/9505091
Brocker, T. (1997). Survival of mature CD4 T lymphocytes is dependent on major histocompatibility complex class II-expressing dendritic cells. J Exp Med 186:1223-1232.
https://www.ncbi.nlm.nih.gov/pubmed/9334361
Riedinger, M., Karjalainen, K., and Brocker, T. (1997). Targeted expression of MHC class II genes to dendritic cells in vivo. Immunol Lett 57:155-158.
https://www.ncbi.nlm.nih.gov/pubmed/9232444
Brocker, T., Riedinger, M., and Karjalainen, K. (1997a). Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo. J Exp Med 185:541-550.
https://www.ncbi.nlm.nih.gov/pubmed/9053454
Brocker, T., Riedinger, M., and Karjalainen, K. (1997b). Driving gene expression specifically in dendritic cells. Adv Exp Med Biol 417:55-57.
https://www.ncbi.nlm.nih.gov/pubmed/9286337
Ng, D.H., Jabali, M.D., Maiti, A., Borodchak, P., Harder, K.W., Brocker, T., Malissen, B., Jirik, F.R., and Johnson, P. (1997). CD45 and RPTPalpha display different protein tyrosine phosphatase activities in T lymphocytes. Biochem J 327 ( Pt 3):867-876.
https://www.ncbi.nlm.nih.gov/pubmed/9581568
Kirberg, J., and Brocker, T. (1996). CD45 up-regulation during lymphocyte maturation. Int Immunol 8:1743-1749.
https://www.ncbi.nlm.nih.gov/pubmed/8943569
Brocker, T., Riedinger, M., and Karjalainen, K. (1996). Redirecting the complete T cell receptor/CD3 signaling machinery towards native antigen via modified T cell receptor. Eur J Immunol 26:1770-1774.
https://www.ncbi.nlm.nih.gov/pubmed/8765019
Brocker, T., and Karjalainen, K. (1995). Signals through T cell receptor-zeta chain alone are insufficient to prime resting T lymphocytes. J Exp Med 181:1653-1659.
https://www.ncbi.nlm.nih.gov/pubmed/7722445
Brocker, T., Peter, A., Traunecker, A., and Karjalainen, K. (1993). New simplified molecular design for functional T cell receptor. Eur J Immunol 23:1435-1439.
https://www.ncbi.nlm.nih.gov/pubmed/8325320
Lane, P., Brocker, T., Hubele, S., Padovan, E., Lanzavecchia, A., and McConnell, F. (1993). Soluble CD40 ligand can replace the normal T cell-derived CD40 ligand signal to B cells in T cell-dependent activation. J Exp Med 177:1209-1213.
https://www.ncbi.nlm.nih.gov/pubmed/7681469
Wegener, A.M., Letourneur, F., Hoeveler, A., Brocker, T., Luton, F., and Malissen, B. (1992). The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules. Cell 68:83-95.
https://www.ncbi.nlm.nih.gov/pubmed/1531041
Pawelec, G., Brocker, T., Busch, F.W., Buhring, H.J., Fernandez, N., Schneider, E.M., and Wernet, P. (1988a). "Tolerization" of human T-helper cell clones by chronic exposure to alloantigen: culture conditions dictate autocrine proliferative status but not acquisition of cytotoxic potential and suppressor-induction capacity. J Mol Cell Immunol 4:21-34.
https://www.ncbi.nlm.nih.gov/pubmed/2977949
Pawelec, G., Fernandez, N., Brocker, T., Schneider, E.M., Festenstein, H., and Wernet, P. (1988b). DY determinants, possibly associated with novel class II molecules, stimulate autoreactive CD4+ T cells with suppressive activity. J Exp Med 167:243-261.
https://www.ncbi.nlm.nih.gov/pubmed/2450156
