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Research Topics and Financial Support

Negative selection versus induction of regulatory T cells

It is well established that encounter of self-antigen during intrathymic development can lead to the “suicide” of potentially dangerous, autoreactive T cells. However, some T cells with specificity for self-antigens are spared from deletion and instead differentiate into so-called regulatory T cells. The parameters that influence the choice between these mechanisms of tolerance are not understood. One of our goals is to elucidate the developmental cues (stromal interaction partner, signal strength, maturation state) that control this developmental decision.