Research topics and Financial Support
Inflammation
Phosphatidylserine (PS) is a plasma membrane component actively retained at the inner membrane surface in living cells. PS retention stops, for example, during cell death or when cells release PS-containing microparticles. Then PS relocates to the outer layer of the cell membrane, where it can interact with extracellular proteins. PS causes thrombin formation, coagulation, activation of the complement system, and inflammation. We study the contribution of these processes to inflammation, immunity, and pathology.